Sort   by:  
 Page size 
ProteomicsSpastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation
Hereditary Spastic Paraplegia (HSP) is a neurodegenerative disease most commonly caused by autosomal dominant mutations in the SPG4 gene encoding the microtubule severing protein spastin. We hypothesise that SPG4-HSP is attributable to reduced spastin function due to haploinsufficiency, thus therape...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2020-10-22 | PXD021945 | Pride
Ubiquitination Spastin Hipk2 Spg4-hsp Protesomal degradation 
ProteomicsSpastin is an essential regulator of male meiosis, acrosome formation, manchette structure and nuclear integrity
The development and function of male gametes is critically dependent on a dynamic microtubule network, yet how this is regulated remains poorly understood. We have recently shown that microtubule severing, via the action of the meiotic AAA ATPase protein clade, plays a critical role in this process....
ORGANISM(S): Mus musculus (Mouse) 
2023-03-22 | PXD038779 | Pride
Mouse Spast Testes Lc-ms/ms 
UnknownSpastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis.
Not available
S-EPMC11382127 | biostudies-literature
UnknownSpastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation.
Not available
S-EPMC7652396 | biostudies-literature
UnknownThe lncRNA MALAT1/miR-30/Spastin Axis Regulates Hippocampal Neurite Outgrowth.
Not available
S-EPMC7606917 | biostudies-literature
UnknownHIPK2 Phosphorylates the Microtubule-Severing Enzyme Spastin at S268 for Abscission.
Not available
S-EPMC6678495 | biostudies-literature
TranscriptomicsA patient-derived neural stem cell model for hereditary spastic paraplegia
Hereditary Spastic Paraplegia (HSP) leads to progressive gait disturbances with lower limb muscle weakness and spasticity. Mutations in SPG4 are a major cause of autosomal-dominant HSP. Spastin, the protein encoded by SPG4, is a microtubule-severing protein and is enriched in the distal axon of cor...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-TABM-1180 | biostudies-arrayexpress
UnknownSpastin binds to lipid droplets and affects lipid metabolism.
Not available
S-EPMC4395272 | biostudies-literature
UnknownSpastin MIT Domain Disease-Associated Mutations Disrupt Lysosomal Function.
Not available
S-EPMC6856053 | biostudies-literature
UnknownESCRT-III-associated proteins and spastin inhibit protrudin-dependent polarised membrane traffic.
Not available
S-EPMC7320071 | biostudies-literature
Sort   by:  
 Page size