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TranscriptomicsTranscription profiling of human 293T cells transfected with HIPK2 or an empty vector and exposed to either hypoxia or normoxia conditions
To determine the consequences of hypoxia-mediated HIPK2 clearance on gene expression, cells 293T were transfected with either the HIPK2 expression vector or the corresponding empty vector and then subjected to either hypoxia conditions (2% O2 for 6 h) or normoxia conditions. RNA total was extracted ...
ORGANISM(S): Homo sapiens 
2009-01-05 | E-MEXP-1896 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the TEC-specific Hipk2 gene knockout in mouse medullary thymic epithelial cells (mTECs)
Analysis of the role of Hipk2 in regulating gene expression in medullary thymic epithelial cells. The whole genome gene signatures of purified mTEC subsets (CD80 low, CD80 high) from TEC-specific Hipk2 knockout mice were compared to mating wildtype control mice (floxed, Cre-). Results provide the up...
ORGANISM(S): Mus musculus 
2015-01-05 | E-GEOD-63432 | biostudies-arrayexpress
TranscriptomicsTranscriptional Corepressors HIPK1 and HIPK2 Control Angiogenesis via TGF-b-TAK1-depdendent Mechanism
Transforming growth factor-b (TGF-b) regulates various aspects of vascular development, yet the signaling mechanisms of TGF-b in the control of angiogenesis remain poorly characterized. Here we show that homeodomain interacting protein kinases, HIPK1 and HIPK2, are transcriptional corepressors that ...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-39253 | biostudies-arrayexpress
GenomicsCardiomyocyte HIPK2 Maintains Basal Cardiac Function via ERK Signaling
Cardiomyocyte HIPK2 Maintains Basal Cardiac Function via ERK Signaling
PRJNA562152 | ENA
TranscriptomicsHIPK2 and MED19 are new regulators of androgen receptor in prostate cancer cells
The androgen receptor (AR) is a mediator of both androgen-dependent and castration- resistant prostate cancers. Identification of cellular factors affecting AR transcriptional activity could in principle yield new targets that reduce AR activity and combat prostate cancer, yet a comprehensive analy...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-GEOD-43881 | biostudies-arrayexpress
TranscriptomicsMurine fetal liver TER119-negative erythroid precursors: Hipk1 or Hipk2 knockdown versus control
Expression profiling of fetal liver erythroid precursors after either Hipk1 or Hipk2 knockdown by shRNA versus control shRNA Two condition experiment, Hipk1 or Hipk2 knockdown versus control (shRNA against luciferase), two replicates each shRNA
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-17106 | biostudies-arrayexpress
GenomicsmRNA profiling upon knockdown of circRNA-HIPK2
mRNA profiling upon knockdown of circRNA-HIPK2
PRJNA1274870 | ENA
GenomicsSystems approach identifies HIPK2 as a critical regulator of kidney tubulointerstitial fibrosis
Systems approach identifies HIPK2 as a critical regulator of kidney tubulointerstitial fibrosis
PRJNA150661 | ENA
TranscriptomicsEvaluation of HIPK2-modulated genes in cancer cells.
HIPK2, a member of the homeodomain-interacting protein kinase family, is a transcriptional corepressor whose activity inhibits tumor progression and allows tumor cell apoptosis in response to chemotherapy. HIPK2 regulates the function of numerous molecules and its inhibition by siRNA, hypoxia or mut...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-31089 | biostudies-arrayexpress
ProteomicsHIPK2 loss promotes TDP-43 cytoplasmic mis-localization through MAPK-pathway and is associated with TDP-43 proteinopathy in vivo
This project investigates the role of HIPK2 in regulating TDP-43 localization. This part of the study focused on: 1. Performing interactome analysis of TDP-43 in Control (Ctrli) and HIPK2-silenced (HIPK2i) SH-SY5Y cells; 2. Characterizing phosphorylation, acetylation and ubiquitination events on TDP...
ORGANISM(S): Homo sapiens (Human) 
2026-10-01 | PXD077595 | Pride
Amyotrophic lateral sclerosis  tdp-43  hipk2  mapk  mouse models  neurodegeneration. 
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