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ProteomicsNegative regulation of Type I IFN signaling by phosphorylation of STAT2 on T387
The samples were derived from STAT2 IP experiments from human fibrosarcoma cells. This experiment involved the transfection of cells with a flag tagged STAT2 and the goal of these experiments is to identify STAT2 binding partners.
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005008 | Pride
Stat2 Phosphorylation 
UnknownOptimising recruitment in clinical trials for progressive multiple sclerosis: observational analysis from the MS-SMART and MS-STAT2 randomised controlled trials.
Not available
S-EPMC9361231 | biostudies-literature
TranscriptomicsExpression data from primary human dermal fibroblasts with STAT2 deficiency and control fibroblasts treated with interferon
Primary human dermal fibroblasts were isolated from an individual showing a genetic defect in innate antiviral immunity associated with profound failure of type 1 interferon signaling and absence of the STAT2 protein. The transcriptional response of these cells to a 10h treatment with interferon-alp...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-41960 | biostudies-arrayexpress
ProteomicsStructure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism
Human cytomegalovirus (CMV) is a highly relevant pathogen, and its rodent counterparts serve as common infection models. Global proteome profiling of rat CMV (RCMV)-infected cells uncovered a pronounced loss of the transcription factor STAT2, which is crucial for interferon signalling. Deletion muta...
ORGANISM(S): Cellular Organisms 
2022-12-15 | PXD033366 | JPOST Repository
GenomicsIdentification of a STAT2 transcriptome in HCT116 p53 null tumor xenografts
Identification of a STAT2 transcriptome in HCT116 p53 null tumor xenografts
PRJNA564684 | ENA
GenomicsSevere type 1 interferonopathy due to germline STAT2 gain-of-function
Severe type 1 interferonopathy due to germline STAT2 gain-of-function
PRJEB29090 | ENA
GenomicsSTAT2 Signaling Regulates Macrophage Phenotype during Influenza and Bacterial Super-infection
STAT2 Signaling Regulates Macrophage Phenotype during Influenza and Bacterial Super-infection
PRJNA487801 | ENA
GenomicsIntron retention regulates STAT2 function and predicts response to immunotherapy in lung
Intron retention regulates STAT2 function and predicts response to immunotherapy in lung
PRJNA1302579 | ENA
GenomicsIntron retention regulates STAT2 function and predicts response to immunotherapy in lung
Intron retention regulates STAT2 function and predicts response to immunotherapy in lung
PRJNA1302578 | ENA
TranscriptomicsComparative Gene expression analysis of 2fTGH cells expressing Wild type STAT2 vs S734A-STAT2 in response to IFN-α or TNF-α
STAT2 is an essential transcription factor in type I interferon (IFN) signaling. STAT2 is activated following exposure to IFN stimulation by phosphorylation at tyrosine-690. This post-translational modification permits the assembly and nuclear retention of the ISGF3 complex (consisting of STAT1/STAT...
ORGANISM(S): Homo sapiens 
2015-10-01 | GSE57017 | GEO
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