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MetabolomicsVariations in carbon flux allocation among cassava (Manihot esculenta) cultivars arise from balanced competition between starch accumulation and structural component development

Cassava (Manihot esculenta Crantz) storage roots exhibit significant variation in starch content among cultivars, yet the metabolic and molecular mechanisms governing carbon allocation between storage and structural components remain poorly understood. Here, we investigated carbon partitioning in...

2025-12-20 | MTBLS13541 | MetaboLights
GenomicsStructural stability based deep sequencing of 5 protein targets
Structural stability based deep sequencing of 5 protein targets
PRJNA1045539 | ENA
GenomicsSystematic Discovery of Structural Elements Governing Mammalian mRNA Stability
Systematic Discovery of Structural Elements Governing Mammalian mRNA Stability
PRJNA152199 | ENA
TranscriptomicsRegulatory consequences of TARBP2 knock-down in MDA-LM2 cell-line [stability experiment]
siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant increase in the stability of sRSE-carrying transcripts. Two independent siRNAs were used to knock down TARBP2 in metastatic MDA-LM2 cells. The cells were then subjected to whole...
ORGANISM(S): Homo sapiens 
2014-07-24 | E-GEOD-49612 | biostudies-arrayexpress
TranscriptomicsSystematic Discovery of Structural Elements Governing Mammalian mRNA Stability
Decoding post-transcriptional regulatory programs underlying gene expression is a crucial step toward a predictive dynamical understanding of cellular state transitions. Despite recent systematic efforts, the sequence determinants of such mechanisms remain largely uncharacterized. An important obsta...
ORGANISM(S): Homo sapiens 
2012-02-28 | E-GEOD-35800 | biostudies-arrayexpress
TranscriptomicsChanges in mRNA Stability Associated with Cold Stress in Arabidopsis Cells
Control of mRNA half-life is a powerful strategy to adjust individual mRNA levels to various stress conditions, because the mRNA degradation rate controls not only the steady-state mRNA level but also the transition speed of mRNA levels. Here, we analyzed mRNA half-life changes in response to cold s...
ORGANISM(S): Arabidopsis thaliana 
2012-12-16 | E-GEOD-31837 | biostudies-arrayexpress
ProteomicsPositional proteomics reveals differences in N-terminal proteoform stability.
To understand the impact of alternative translation initiation on a proteome, we performed the first large-scale study of protein turnover rates in which we distinguish between N-terminal proteoforms pointing to translation initiation events. Using pulsed SILAC combined with N-terminal COFRADIC we m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-13 | MSV000083565 | MassIVE
TranscriptomicsAn analysis of genomic structural alteration in three human ES cell lines.
To elucidate frequencies of genomic structural alterations, we performed an analysis using a SNP genotyping array (Illumina HumanCytoSNP-12 v2.1 DNA Analysis BeadChip Kit) for three human ES cell lines, namely, SEES-1, SEES-2, and SEES-3. Samples were collected after 4 to 60 passages to detect struc...
ORGANISM(S): Homo sapiens 
2015-05-20 | E-GEOD-54576 | biostudies-arrayexpress
ProteomicsStructural perturbation at the N-terminal domain of human phosphoglycerate kinase 1 reduces the kinetic stability and unfolding cooperativity of a two-domain enzyme
Phosphoglycerate kinase has been a model for the stability, folding cooperativity and catalysis of a two-domain protein. The human isoform 1 (hPGK1) is associated with cancer development and rare genetic diseases that affect several of their features. To investigate how mutations affect hPGK1 foldin...
ORGANISM(S): Homo sapiens (Human) 
2022-11-03 | PXD035628 | Pride
Protein folding  structural perturbation  disease 
TranscriptomicsStructural basis of YTH domain as m6A reader
The N6-methyladenosine (m6A) is the most abundant internal modification in almost all eukaryotic messenger RNAs, and is dynamically regulated. Therefore, identification of m6A readers is especially important in determining the cellular function of m6A. YTHDF2 has recently been characterized as the f...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-58352 | biostudies-arrayexpress
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