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TranscriptomicsTranscription profiling of mouse to predict left ventricle systolic dysfunction using gene expression profiling
We tested the hypothesis that a set of differentially expressed genes could be used to predict cardiovascular phenotype in mice after prolonged catecholamine stress. Experiment Overall Design: We observed that WT FVB and B2KO mice developed systolic dysfunction in response to continuous catecholamin...
ORGANISM(S): Mus musculus 
2009-10-26 | E-GEOD-12413 | biostudies-arrayexpress
GenomicsLionheart LincRNA Alleviates Cardiac Systolic Dysfunction under Pressure Overload
Lionheart LincRNA Alleviates Cardiac Systolic Dysfunction under Pressure Overload
PRJNA644194 | ENA
TranscriptomicsCardiac 12/15-lipoxygenase-induced inflammation is involved in heart failure
To identify a novel target for the treatment of heart failure, we examined gene expression in the failing heart. Among the genes analyzed, 12/15 lipoxygenase (12/15-LOX) was markedly up-regulated in heart failure. To determine whether increased expression of 12/15-LOX causes heart failure, we establ...
ORGANISM(S): Rattus norvegicus 
2009-06-06 | E-GEOD-16199 | biostudies-arrayexpress
ProteomicsUnusual cardiac myosin heavy chain post-translational modifications with systolic heart failure
In the present study, we aimed at defining whether cardiac myosin heavy chain (MYH7) post-translational modifications would be altered in systolic heart failure. For that, we had access to septal tissue from donors and from patients with non-genetic dilated cardiomyopathy or with ischemic cardiomyop...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD076695 | Pride
Heart failure  systolic dysfunction  myh7  myosin 
GenomicsCD163+ cardiac macrophages attenuate pressure overload-induced left ventricular systolic dysfunction via interleukin-10
CD163+ cardiac macrophages attenuate pressure overload-induced left ventricular systolic dysfunction via interleukin-10
PRJNA1162930 | ENA
TranscriptomicsTransition from Compensated Hypertrophy to Systolic Heart Failure in the Spontaneously Hypertensive Rat
Full Title: Transition from Compensated Hypertrophy to Systolic Heart Failure in the Spontaneously Hypertensive Rat: Structure, Function, and Transcript Analysis Gene expression changes and left ventricular remodeling associated with the transition to systolic heart failure (HF) were determined in ...
ORGANISM(S): Rattus norvegicus 
2010-02-21 | E-GEOD-19210 | biostudies-arrayexpress
GenomicsLeft ventricular systolic dysfunction in female NBCe1-B/C-knockout mice
Left ventricular systolic dysfunction in female NBCe1-B/C-knockout mice
PRJNA925818 | ENA
GenomicsMus musculus
Prediction of left ventricle systolic dysfunction in mice using gene expression profiling
PRJNA113103 | ENA
TranscriptomicsTranscription profiling of rat ventricle samples from streptozotocin (STZ)-diabetic animals to investigate mitochondrial long-chain free fatty acid export
Cardiomyopathy in type 1 diabetic patients is characterized by early onset diastolic and late onset systolic dysfunction. The mechanism underlying development of diastolic and systolic dysfunction in diabetes remains unknown. We used microarrays to detail the ventricle gene expression changes that ...
ORGANISM(S): Rattus norvegicus 
2007-11-29 | E-GEOD-4745 | biostudies-arrayexpress
TranscriptomicsRNA-seq of myocardial tissue from abdominal aortic-banded rats with and without systolic heart failure
In the present study we aimed to investigate whether alterations in left ventricular myocardial micro-RNA (miRNA) expression and post-transcriptional gene regulation might contribute to the development of systolic heart failure in aortic-banded (AB) rats. Hence, in young adult male Sprague-Dawley ra...
ORGANISM(S): Rattus norvegicus 
2023-05-24 | E-MTAB-12671 | biostudies-arrayexpress
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