Transition from Compensated Hypertrophy to Systolic Heart Failure in the Spontaneously Hypertensive Rat

ABSTRACT: Full Title: Transition from Compensated Hypertrophy to Systolic Heart Failure in the Spontaneously Hypertensive Rat: Structure, Function, and Transcript Analysis Gene expression changes and left ventricular remodeling associated with the transition to systolic heart failure (HF) were determined in the spontaneously hypertensive rat (SHR). By combining transcriptomics of left ventricles from six SHR with HF with changes in function and structure we aimed to better understand the molecular events underlying the onset of systolic HF compared to six age-matched, SHR with compensated hypertrophy. Left ventricle (LV) ejection fraction was depressed (82±4 to 52±3 %) in compensated vs. failing animals.  Systolic blood pressure decreased and LV end-diastolic and systolic volume increased with

ORGANISM(S): Rattus norvegicus

SUBMITTER: steve shen 

PROVIDER: E-GEOD-19210 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress