Cannabidiol (CBD) showed antiproliferative activity and induction of apoptosis in chronic myelogenous leukaemia cancer cells (K562 cells). A consolidated DARTS (Drug Affinity Response Target Stability) and t-LIP-MRM (targeted- Limited Proteolysis-Multiple Reaction Monitoring Mass spectrometry) platf...
Objective: Chronic periodontitis typically affects individuals aged 40–50. Aging impairs immunity, sustains chronic inflammation, and enhances autoimmunity, a process called "immunosenescence", which contributes to the development of type 2 diabetes and rheumatoid arthritis (RA). Thymic involution a...
BCG therapy is the most effective immunotherapy for bladder cancer, but it sometimes causes serious adverse events because of infection with live BCG bacteria. To develop more effective and less toxic immunotherapeutic agents, we have developed formulations using BCG cell wall components. Trehalose ...
This study aimed to evaluate a TLR7 agonist liposome (1V209-Cho-Lip) for its anti-metastatic effects and mechanisms in osteosarcoma. Single-cell transcriptomics analysis demonstrated that treatment with 1V209-Cho-Lip alleviates myeloid-mediated immunosuppression, promotes CD8+ T cell activation and ...
Here we report that Dectin-1-stimulated dendritic cells (DCs) induce unique IL-10-producing T cells with strong regulatory function during fungal infection or experimental asthma.These T cells, which we call Dectin-10 T cells, are induced by DC-initiated signaling that sets in motion two complementa...
Purpose: T cells undergo intense proliferation in the setting of lymphopenia and chemotherapy pre-conditioning is therefore an essential component of CAR-T therapy. Lymphopenia-induced proliferation (LIP) is thought to be mediated primarily by homeostatic cytokines such as IL-7 and IL-15 but little ...
Emerging evidence indicates that gingival-resident helper CD4+ T cells are major drivers of periodontal inflammation in response to commensal and pathogenic oral microorganisms. Whether tissue-resident memory CD8+ T cells (TRM), which principally safeguard against viruses and cancer but also drive c...
