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UnknownTAK228 enhances antitumor activity of eribulin in triple negative breast cancer.
Not available
S-EPMC6707945 | biostudies-literature
UnknownThe TORC1/2 inhibitor TAK228 sensitizes atypical teratoid rhabdoid tumors to cisplatin-induced cytotoxicity.
Not available
S-EPMC5604899 | biostudies-literature
UnknownThe dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma.
Not available
S-EPMC5569904 | biostudies-literature
UnknownDICE: Dual mTorc Inhibition in advanCed/recurrent Epithelial ovarian cancer resistant to standard treatment-a study protocol for a randomised trial investigating a novel therapy called TAK228.
Not available
S-EPMC8980506 | biostudies-literature
ProteomicsUnbiased proteomic and phosphoproteomic analysis identifies response signatures and novel susceptibilities after combined MEK and mTOR inhibition in BRAFV600E mutant glioma
The mitogen-activated protein kinase (MAPK) pathway is one of the most altered pathways in cancer. It is involved in the control of cell proliferation, invasion, metabolism, and resistance to therapy. A number of aggressive malignancies, including melanoma, colon cancer and glioma, are driven by an ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-07-30 | PXD022329 | Pride
Glioma  braf v600e  trametinib  tak228  sapanisertib  ink128  mln0128 
UnknownTORC1/2 kinase inhibition depletes glutathione and synergizes with carboplatin to suppress the growth of MYC-driven medulloblastoma.
Not available
S-EPMC9195565 | biostudies-literature
TranscriptomicsMacropinocytosis and vascularization detrmine response to mTOR inhibitors in lung squamous cell carcinomas
Resistance to small molecule inhibitors targeting key metabolic pathways in lung tumors remains a significant challenge in personalized cancer therapy. In this study, we investigated the mechanisms of resistance to the small molecule mTOR inhibitor TAK228 across lung squamous cell carcinoma (LUSC) c...
ORGANISM(S): Homo sapiens 
2025-12-02 | GSE292426 | GEO
UnknownA platinum@polymer-catechol nanobraker enables radio-immunotherapy for crippling melanoma tumorigenesis, angiogenesis, and radioresistance.
Not available
S-EPMC9513621 | biostudies-literature
GenomicsMacropinocytosis and vascularization detrmine response to mTOR inhibitors in lung squamous cell carcinomas
Macropinocytosis and vascularization detrmine response to mTOR inhibitors in lung squamous cell carcinomas
PRJNA1238384 | ENA
UnknownSynergistic activity of mTORC1/2 kinase and MEK inhibitors suppresses pediatric low-grade glioma tumorigenicity and vascularity.
Not available
S-EPMC7158655 | biostudies-literature
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