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MetabolomicsStreamlined identification of strain engineering targets for bioprocess improvement using metabolic pathway enrichment analysis
Metabolomics is a powerful tool for the identification of genetic targets for bioprocess optimisation. However, in most cases, only the biosynthetic pathway directed to product formation is analysed, limiting the identification of these targets. Some studies have used untargeted metabolomics, allowi...
2023-08-31 | MTBLS6667 | MetaboLights
MetabolomicsTargeted metabolomic analysis on hexosamine biosynthetic pathway in flies on time restricted feeding
Not available
ORGANISM(S): Drosophila melanogaster 
ST001452 | MetabolomicsWorkbench
Metabolomicswidely targeted metabolomic analysis

Based on widely targeted metabolomic analysis, we explored the differences in metabolite composition and content of tomato fruits with different genotypes or exogenous metabolites were added. In addition, we also investigated the effects of different treatments on the composition and content of b...

2025-12-14 | MTBLS13506 | MetaboLights
MetabolomicsTargeted metabolomics analysis by LC-MS/MS for BMDCs infected with VSV
Virus-infected cells often exhibit dramatic cellular changes accompanied by altered mitochondrial function. The contribution of factors shaping the inner mitochondrial membrane (IMM) and cristae architecture on viral replication is insufficiently understood. Single cell transcriptomics applying vesi...
2025-06-18 | MTBLS12438 | MetaboLights
MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15770 | MetaboLights
MetabolomicsDiverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood
During human fasting, metabolic markers, including butyrates, carnitines, and branched-chain amino acids, are upregulated for energy substitution through gluconeogenesis and use of stored lipids. We performed non-targeted, accurate semiquantitative metabolomic analysis of human whole blood, plasma, ...
2019-09-11 | MTBLS549 | MetaboLights
MetabolomicsIntegrated multi-omics analysis and experimental verification reveal the involvement of the PI3K/Akt signaling pathway in myometrial fibrosis of adenomyosis.

This analysis established comprehensive metabolomic profiles of adenomyosis patients and revealed widespread alterations in the metabolome within normal and fibrotic myometrium. Integrated analysis shown significant associations between metabolomic data and fibrosis . This study is the first to d...

2025-05-12 | MTBLS11965 | MetaboLights
MetabolomicsFlavonoid-targeted metabolomic analysis.

Flavonoids, one of the major groups of root exudates, are active molecules mediating plant-PGPR interactions. Flavonoids can alleviate nutrient deficiencies and drought stress to maintain normal plant growth. Here, We used flavonoid targeted metabolomic analysis to profile flavonoid components an...

2025-12-14 | MTBLS13507 | MetaboLights
MetabolomicsComplete pathway elucidation and heterologous reconstitution of Rhodiola salidroside biosynthesis
Salidroside is a bioactive tyrosine-derived phenolic natural product found in medicinal plants under the Rhodiola genus. In addition to their roles in traditional medicine as anti-fatigue and anti-anoxia adaptogens, Rhodiola total extract and salidroside have also displayed medicinal properties as a...
2018-01-25 | MTBLS566 | MetaboLights
MetabolomicsComparative analysis of rhizosphere soil between three plantation types in Karst Rocky Desertification area by widely targeted metabolomics

Understanding the differences in rhizosphere soil microbial metabolites between severely and mildly rocky desertified areas is crucial for developing ecological restoration strategies and land management measures in rocky desertification regions. This study systematically analyzed the differences...

2025-02-24 | MTBLS11482 | MetaboLights
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