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MetabolomicsOperation of a TCA cycle subnetwork in the mammalian nucleus

Nucleic acid and histone modifications critically depend on tricarboxylic acid (TCA) cycle for substrates and co-factors. Although a few TCA cycle enzymes have been reported in the nucleus, the corresponding pathways are considered to operate in mitochondria. Here, we show that a part of the...

2022-06-15 | MTBLS2235 | MetaboLights
MetabolomicsMitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling flux of the TCA cycle

To elucidate the function of oxidative phosphorylation (OxPhos) during B-cell differentiation we employ CD23Cre-driven expression of the dominant-negative K320E mutant of the mitochondrial helicase Twinkle (DNT). DNT-expression depletes mitochondrial DNA during B cell maturation, reduces the abun...

2026-08-21 | MTBLS4647 | MetaboLights
MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
MetabolomicsEffects of Exercise on Dystrophic Mouse Muscle TCA Cycle (part II)
Not available
ORGANISM(S): Mus musculus 
ST000646 | MetabolomicsWorkbench
MetabolomicsControl of Topoisomerase II Activity and Chemotherapeutic Inhibition by TCA Cycle Metabolites
Not available
ORGANISM(S): Saccharomyces cerevisiae 
ST001658 | MetabolomicsWorkbench
MetabolomicsMeasuring TCA cycle concentrations in insulin resistant and insulin deficient mouse tissue models
Not available
ORGANISM(S): Mus musculus 
ST000520 | MetabolomicsWorkbench
MetabolomicsEffects of NO Donor Therapy on the Dystrophic Mouse Muscle TCA Cycle (part VI)
Not available
ORGANISM(S): Mus musculus 
ST000650 | MetabolomicsWorkbench
MetabolomicsTCA Cycle Metabolites of Dietary Salt Effects on Blood Pressure in Rat Urine (part IV)
Not available
ORGANISM(S): Rattus norvegicus 
ST000631 | MetabolomicsWorkbench
MetabolomicsQuantitative measurements of TCA cycle metabolites in T1D poor control, good control, and controls.
Not available
ORGANISM(S): Homo sapiens 
ST000443 | MetabolomicsWorkbench
MetabolomicsMitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling flux of the TCA cycle
Not available
ORGANISM(S): Mus musculus 
ST002140 | MetabolomicsWorkbench
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