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ProteomicsTcdB of Clostridioides difficile mediates necrosis in epithelial cells and is depend on RAS
A Clostridioides difficile infection (CDI) is the most common nosocomial infection worldwide. The main virulence factors are TcdA and TcdB, which inhibit small Rho-GTPases. Inhibition of small Rho-GTPases leads to the so-called cytopathic effect, a reorganization of the actin cytoskeleton, an impair...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD031726 | Pride
Clostridioides difficile  c.diff.  tcdb  phosphoproteomics  ras  tcda  pyknosis  glucosyltransferase independent effect 
GenomicsEarly cell death induced by Clostridium difficile TcdB
Early cell death induced by Clostridium difficile TcdB
PRJNA433240 | ENA
TranscriptomicsEarly cell death induced by Clostridium difficile TcdB
This study primarily shows the transcripts for all genes possibly involved in uptake of C. difficile TcdB. The long term effect of the second receptor binding domain (aa 1101-1873) of TcdB (2 µg/ml) on Hep-2 cells was investigated after 72 hours of incubation.
ORGANISM(S): Homo sapiens 
2018-05-31 | GSE110242 | GEO
GenomicsTranscript changes in human pericytes exposed to Clostridioides difficile TcdB and an Hippo signaling inhibitor.
Transcript changes in human pericytes exposed to Clostridioides difficile TcdB and an Hippo signaling inhibitor.
PRJNA1299296 | ENA
TranscriptomicsTranscript changes in human pericytes exposed to Clostridioides difficile TcdB and an Hippo signaling inhibitor.
These experiments are designed to profile of how TcdB and XMU-MP-1 modify gene expression in pericytes. TcdB is a bacterial toxin and primary virulence factor produced by the enteric pathogen C. difficile, and pericytes are putative target cells for TcdB in the colon. XMU-MP-1 is an inhibitor of a c...
ORGANISM(S): Homo sapiens 
2026-02-11 | GSE304120 | GEO
GenomicsCTCF (CCCTC-binding factor) binding patterns in the human genome following exposures to Clostridioides difficile TcdB.
This experiment uses a CUT&RUN approach to determine if the CCCTC-binding factor (CTCF) is altered in its ability to bind the human genome following exposure to TcdB. TcdB is a bacterial toxin and primary virulence factor produced by the enteric pathogen C. difficile. CTCF is a DNA binding protein t...
ORGANISM(S): Homo sapiens 
2026-02-11 | GSE304121 | GEO
GenomicsCTCF (CCCTC-binding factor) binding patterns in the human genome following exposures to Clostridioides difficile TcdB.
CTCF (CCCTC-binding factor) binding patterns in the human genome following exposures to Clostridioides difficile TcdB.
PRJNA1299299 | ENA
Genomics
Pathogenic Clostridioides spp. (tcdC-/tcdB+)
PRJNA1297032 | ENA
UnknownVariations in TcdB activity and the hypervirulence of emerging strains of Clostridium difficile.
Not available
S-EPMC2924371 | biostudies-literature
UnknownLectin Activity of the TcdA and TcdB Toxins of Clostridium difficile.
Not available
S-EPMC6386544 | biostudies-literature
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