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TranscriptomicsNuclear Transfer nTreg model reveals fate-determining TCRbeta and peripheral nTreg precursors
To study the development and function of â??natural-arisingâ?? T regulatory (nTreg) cells, we developed a novel nTreg model on pure nonobese diabetic background using epigenetic reprogramming via somatic cell nuclear transfer. On RAG1-deficient background, we found that monoclonal FoxP3+ CD4+ Treg c...
ORGANISM(S): Mus musculus 
2016-04-04 | E-GEOD-70156 | biostudies-arrayexpress
ProteomicsArabidopsis chloroplast comparison by Masuda and Luu 2020
Relative comparison of the isolated chloroplasts between wild-type and tcr mutant in Arabidopsis: IDA and SWATH measurement
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2021-04-02 | PXD020752 | JPOST Repository
TranscriptomicsGene expression in Galectin-3 KO vs. WT CD8 T cells
The goal of this study was to examine differences in gene expression of tumor specific CD8 T cells in an in vivo tumor mouse model after inhibition of galectin-3 protein expression by genetic knockout. Galectin-3 is thought to modulate CD8 T cell response by cross-linking cell surface glycoproteins...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-59454 | biostudies-arrayexpress
TranscriptomicsExpression data from virus-specific mouse Th1 and Tfh CD4 T cell subsets after LCMV infection
CD4 T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for longlived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh lineage after antigen clearance. Using adoptive transf...
ORGANISM(S): Mus musculus 
2013-04-22 | E-GEOD-43863 | biostudies-arrayexpress
ProteomicsA library of novel Cancer Testis specific T cell receptors for T cell receptor gene therapy
Background Clinical success of T cell receptor (TCR) gene therapy has previously been demonstrated for NY-ESO-1 TCR gene therapy. To increase numbers of cancer patients that can be treated with TCR gene therapy we aimed to identify a novel set of high-affinity cancer specific TCRs targeting differen...
ORGANISM(S): Homo sapiens (Human) 
2023-01-23 | PXD038862 | Pride
T cell receptor Tcr gene therapy Mage Cd8+ t cells Cancer testis genes 
TranscriptomicsGene expression analysis in adoptive T cell immunotherapy (ACT)
To understand the global effector immune responses in the tumor induced by ACT, we performed a gene chip analysis using B16 melanoma-pmel-1 TCR transgenic T cells model. Gene expression was measured in the tumor from untreated or ACT mice on day 1, 3, 5 and 7. Gene expression was also measured in th...
ORGANISM(S): Mus musculus 
2014-08-25 | E-GEOD-57304 | biostudies-arrayexpress
UnknownGeneration of V α13/β21+T cell specific target CML cells by TCR gene transfer.
Not available
S-EPMC5356659 | biostudies-literature
UnknownA CD22-reactive TCR from the T-cell allorepertoire for the treatment of acute lymphoblastic leukemia by TCR gene transfer.
Not available
S-EPMC5342099 | biostudies-literature
UnknownTCR gene transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 epitopes as melanoma-specific immune targets.
Not available
S-EPMC3287115 | biostudies-literature
UnknownEditing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer.
Not available
S-EPMC5019824 | biostudies-literature
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