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TranscriptomicsMAGE-A1 Promotes Proliferation, Migration and Invasion of Human Melanoma Cells through RNA-SEQ Analysis via Affecting C-JUN-IL8-ARHGAP29 Network
To define the role of MAGE-A1 in melanoma growth and metastasis, we performed RNA-seq analysis on MAGE-A1 overexpression (OE) and knockdown (KD) models in A375 human melanoma cell line. Our results revealed that overexpression of MAGE-A1 dramatically promoted proliferation, migration, and invasion o...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-66859 | biostudies-arrayexpress
GenomicsExploring TCR-like CAR-Engineered Lymphocyte Cytotoxicity against MAGE-A4
Exploring TCR-like CAR-Engineered Lymphocyte Cytotoxicity against MAGE-A4
PRJNA998572 | ENA
TranscriptomicsMAGE-seq E.coli infA amplicon high-throughput genotyping data, mutants from Kelsic et al. Cell Systems, 2016
MAGE-seq amplicon data from the paper RNA structural determinants of optimal codons revealed by MAGE-seq in Cell Systems 2016 by Kelsic, Chung, Cohen, Park, Wang & Kishony. Data contains read counts for PCR amplicons of the Escherichia coli gene infA: 1) Single codon mutants tiling along the entire ...
ORGANISM(S): Escherichia coli 
2016-10-01 | E-MTAB-4020 | biostudies-arrayexpress
TranscriptomicsMAGE-seq E. coli primary sigma factor RpoD amplicon high-throughput genotyping
Genotyping of RpoD mutants via amplicon sequencing from the following manuscript: \\"Systematic dissection of σ70 sequence diversity and function in bacteria\\" by Park and Wang (2020). Includes raw sequencing reads from samples from MAGE-seq single codon saturation mutagenesis and high-throughput f...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2022-06-06 | E-MTAB-9103 | biostudies-arrayexpress
GenomicsStructural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
PRJNA624321 | ENA
TranscriptomicsStructural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases
Testis-restricted melanoma antigen (MAGE) proteins are frequently hijacked in cancer and play a critical role in tumorigenesis. MAGEs assemble with E3 ubiquitin ligases and function as substrate adaptors that direct the ubiquitination of novel targets, including key tumor suppressors. However, how M...
ORGANISM(S): Homo sapiens 
2020-08-15 | GSE148458 | GEO
TranscriptomicsExploring TCR-like CAR-Engineered Lymphocyte Cytotoxicity against MAGE-A4
In this work, we compared the expression profiles of Anti-MAGE-A4- transduced T-cells with Anti-MAGE-A4- transduced T-cells co-cultured with SK-Mel-37.
ORGANISM(S): Homo sapiens 
2023-07-31 | GSE238191 | GEO
TranscriptomicsIdentification of a predictive gene signature to recMAGE A3 antigen-specific cancer immunotherapy in metastatic melanoma and non-small-cell lung cancer
Purpose: To evaluate the presence of a gene expression signature present before treatment as predictive of response to treatment with MAGE‑A3 immunotherapeutic in metastatic melanoma patients and to validate its predictivity in adjuvant therapy of early-stage lung cancer. Patients were participan...
ORGANISM(S): Homo sapiens 
2013-05-30 | E-GEOD-35640 | biostudies-arrayexpress
ProteomicsMAGE-A4 TCR-like antibody immunoprecipitation in A375 and A375 MAGE-A4 KO xenograft tissue
To demonstrate the on-target binding of the MAGE-A4 antibody to the target HLAp GVYDGREHTV, we developed a reverse immunopeptidomics strategy that uses the HLAp-targeting antibody as a bait to enrich interacting HLAp from A375 xenografts. For this purpose, we immobilized the IgG-format of the MAGE-A...
ORGANISM(S): Homo sapiens (Human) 
2024-04-02 | PXD048298 | Pride
Tcr-like antibody Human tissue Immunopeptidomics 
ProteomicsMAGE-A4 TCR-like antibody immunoprecipitation in A375 and A375 MAGE-A4 KO xenograft tissue
To demonstrate the on-target binding of the MAGE-A4 antibody to the target HLAp GVYDGREHTV, we developed a reverse immunopeptidomics strategy that uses the HLAp-targeting antibody as a bait to enrich interacting HLAp from A375 xenografts. For this purpose, we immobilized the IgG-format of the MAGE-A...
ORGANISM(S): Homo sapiens (Human) 
2024-03-30 | PXD048297 | Pride
Tcr-like antibody Human tissue Immunopeptidomics 
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