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TranscriptomicsU-87 MG Temozolomide-Induced Senescence RNA-seq Dataset
We analyzed the U-87 MG cell line, which was treated with temozolomide for 5 days to induce a senescent state. The study aimed to investigate molecular and phenotypic alterations associated with senescence in the context of a malignant phenotype. Senescence was confirmed through β-galactosidase stai...
ORGANISM(S): Homo sapiens 
2025-05-14 | E-MTAB-15106 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human-melanoma derived cell lines response to chemotherapy
To identify patterns of gene expression that correlate with response to treatment with either melphalan or temozolomide we measured both gene expression using microarray genechips and response to drug using a standard in vitro cell proliferation assay. Senstivity to melphalan was measured 48hrs aft...
ORGANISM(S): Homo sapiens 
2009-02-09 | E-GEOD-10916 | biostudies-arrayexpress
GenomicsSingle-nucleotide-resolution genomic maps of O6-methylguanine from the glioblastoma drug temozolomide
Single-nucleotide-resolution genomic maps of O6-methylguanine from the glioblastoma drug temozolomide
PRJNA1047565 | ENA
GenomicsSingle-nucleotide-resolution genomic maps of O6-methylguanine from the glioblastoma drug temozolomide
Single-nucleotide-resolution genomic maps of O6-methylguanine from the glioblastoma drug temozolomide
PRJNA1172681 | ENA
ModelsStephanou2019 - pH as a potential therapeutic target to improve temozolomide antitumor efficacy
Abstract: Despite intensive treatments including temozolomide (TMZ) administration, glioblastoma patient prognosis remains dismal and innovative therapeutic strategies are urgently needed. A systems pharmacology approach was undertaken to investigate TMZ pharmacokinetics‐pharmacodynamics (PK‐PD) inc...
2019-09-30 | MODEL1909300003 | BioModels
TranscriptomicsGene expression analysis of primary human myeloid precursor cells treated with O6-benzylguanine (6BG) and Temozolomide (TMZ)
For the comparison of 6BG/TMZ with control sample, the predominant annotation among the upregulated genes is M-bM-^@M-^XapoptosisM-bM-^@M-^Y. The majority of the downregulated genes is assigned to heat shock proteins and proteins which bind unfolded proteins. To look at early changes in gene express...
ORGANISM(S): Homo sapiens 
2013-06-03 | E-GEOD-44122 | biostudies-arrayexpress
GenomicsEx vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers
Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers
PRJNA971167 | ENA
MetabolomicsConsistency across multi-omics layers in a drug-perturbed gut microbial community
Multi-omics analyses are increasingly employed in microbiome studies to obtain a holistic view of molecular changes occurring within microbial communities exposed to different conditions. However, it is not always clear to what extent each omics data type contributes to our understanding of the comm...
2022-12-08 | MTBLS3129 | MetaboLights
ProteomicsProteomic changes after indicated drug treatment
Protein profile changes of glioma cells treated with temozolomide or albumin-bound paclitaxel were screened by proteomics
ORGANISM(S): Homo Sapiens 
2023-03-28 | PXD041176 |
OtherSingle-nucleotide-resolution genomic maps of O6-methylguanine from the glioblastoma drug temozolomide
Temozolomide kills cancer cells by forming O6-methylguanine (O6-MeG), which leads to apoptosis due to mismatch-repair overload. However, O6-MeG repair by O6-methylguanine-DNA methyltransferase (MGMT) contributes to drug resistance. Genomic profiles of O6-MeG could elucidate how O6-MeG accumulation i...
ORGANISM(S): Homo sapiens 
2023-12-12 | GSE249155 | GEO
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