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Illumina HiSeq 2000 (66)
Illumina HiSeq 2500, ILLUMINA (16)
Illumina HiSeq 2500 (15)
ILLUMINA, Illumina HiSeq 2000 (14)
Illumina HiSeq 2000, ILLUMINA (14)
ILLUMINA, Illumina HiSeq 2500 (11)
Illumina MiSeq (7)
Illumina HiSeq 2500, Illumina HiSeq 2000 (5)
Illumina MiSeq, ILLUMINA (3)
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Aperio (2)
HiSeq X Ten, ILLUMINA (2)
Illumina_450K (2)
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Illumina HiSeq 2000, NextSeq 500, ILLUMINA (2)
Illumina Genome Analyzer IIx, Illumina HiSeq 2000 (2)
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NextSeq 500 (ILLUMINA), Illumina HiSeq 2500 (ILLUMINA) (1)
Illumina HiSeq 2500, Illumina HiSeq 4000, ILLUMINA (1)
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NextSeq 500, Illumina HiSeq 2000, ILLUMINA, Illumina HiSeq 2500 (1)
Illumina MiSeq, Illumina HiSeq 2500, ILLUMINA (1)
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Illumina CytoSNP 12 bead array, nanostring (1)
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Illumina DASL Assay (1)
Illumina Oncoscan Array (1)
ILLUMINA, Illumina HiSeq 1000 (1)

Instrument Platform

Illumina NovaSeq 6000 (534)
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Dell PowerEdge R750; CPU: 2 × Intel Xeon Gold 6346 (32 Cores / 64 Threads); RAM: 188 GB (7)
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NucleoSpin RNA/Protein kit lysis buffer (350 µL per tube; Macherey‑Nagel). (6)
None (6)
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Illumina HiSeq 3000 (6)
See manuscript (5)
FastPrep‑24 homogenizer (MP Biomedicals) (4)
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10x Genomics Chromium Controller (4)

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UNIPROT ID/AC

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ENSEMBL ID

ENSMUST00000021413 (2)
ENSMUST00000019997 (2)
ENSMUST00000025867 (1)
ENSMUST00000029812 (1)
ENSG00000170477 (1)

CHEBI ID

CHEBI:16449 (112)
CHEBI:16027 (111)
CHEBI:18183 (73)
CHEBI:15422 (60)
CHEBI:16675 (57)
CHEBI:17489 (3)
CHEBI:17552 (3)
CHEBI:60425 (2)
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CHEBI:27859 (2)
CHEBI:29200 (2)
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CHEBI:50583 (2)
CHEBI:28061 (2)
CHEBI:27978 (2)
CHEBI:27852 (2)
CHEBI:28037 (2)
CHEBI:16934 (2)
CHEBI:27748 (2)
CHEBI:28259 (2)
CHEBI:1941 (2)
CHEBI:17883 (2)
CHEBI:506227 (2)
CHEBI:18041 (2)
CHEBI:18086 (2)
CHEBI:17514 (2)
CHEBI:16480 (2)

Metabolite Name

Creatine (185)
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L-Valine (111)
L-Threonine (110)
Pantothenic acid (105)

First Public Date

2025 (441)
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2016 (61)
2013 (52)

Modelling Approach

Ordinary differential equation model (26)
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Study status

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Lab affiliation

Alkahest Inc. (7)
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, United States (5)
Vividion Therapeutics (4)
Chair of Proteomics and Bioanalytics Technical University of Munich Emil-Erlenmeyer-Forum 5 85354 Freising Germany (3)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (3)
Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA (3)
Imperial College London (3)
Memorial Sloan Kettering Cancer Center (3)
Novartis Inst. for BioMedical Research (3)
Protein Maturation, Cell fate and Therapeutics, Institute for Integrative Biology of the Cell (I2BC), CNRS UMR9198, Bâtiment 21, 1 Avenue de la Terrasse F-91198 Gif-sur-Yvette CEDEX, France (3)
STORM Therapeutics Limited Cambridge United Kingdom (3)
STORM Therapeutics Limited, Cambridge, United Kingdom (3)
Amphista Therapeutics Cambridge United Kingdom (2)
Center of experimental therapeutics Department of oncology UNIL CHUV Ludwig Institute for Cancer Research Lausanne Centre de recherche Agora Rue du Bugnon 25A CH-1005 Lausanne (2)
Centro de Investigación Príncipe Felipe, Av. Eduardo Primo Yúfera 3, 46012 Valencia, Spain (2)
DTU Bioengineering (2)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (2)
Department of Cellular and Molecular Medicine, University of Copenhagen (2)
Department of Chemistry, Scripps Research, La Jolla, CA 92037 USA (2)
Department of Chemistry, The Scripps Research Institute (2)
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA (2)
Department of Genome Sciences, University of Washington, Seattle, WA 98195 USA (2)
Department of Laboratory Medicine, Wiita Lab, University of California, San Francisco, USA (2)
Department of Molecular Pharmacology and Therapeutics Columbia University Irving Medical Center (2)
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. (2)
Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA (2)
Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. (2)
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA (2)
Departments of Chemistry, Biological Sciences, Microbiology and Immunology, Vanderbilt University (2)
Departments of Pharmacology & Experimental Therapeutics and Neurology Boston University School of Medicine (2)

Keyword

Cancer Vaccine (2)
Vaccine (2)
Locally advanced cancer (2)
Metastatic cancer (2)
STAT3, cancer, inhibitor, advanced cancer (1)
Tissue sample (1)
Stool sample (1)
Blood sample (1)
Small intestine neuroendocrine tumor (1)
Pancreas (1)
Database (1)
Cancer, colorectal, (1)
Palliative surgery (1)
Zaltrap (1)
Aflibercept (1)

IsPrivate

False (45)

Model Flag

Non Kinetic (1)

Submitter Keywords

FROG (3)
TransQST (2)
Ersilia (1)
FAIR-AIML (1)
Machine Learning Model (1)
Not Peer Reviewed (1)
COVID-19 (1)
Immuno-oncology (1)

Classification

bacteria (50)
viruses (15)
fungi (9)
helminths (4)
protozoa (3)

Modification

-17.026549 (1)
15.994915 (1)
4-tetrahydrothiazine-3-carboxylic acid (1)
42.010565 (1)
57.021464 (1)
Not available (1)

Study type

Transcription profiling by array (1752)
RNA-seq of coding RNA (839)
RNA-seq of coding RNA from single cells (194)
RNA-seq of total RNA (107)
ChIP-seq (92)
Comparative genomic hybridization by array (71)
Unknown experiment type (50)
Methylation profiling by array (48)
DNA-seq (45)
RNA-seq of non coding RNA (32)
Other (29)
ATAC-seq (27)
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Genotyping by array (24)
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CUT&RUN (19)
Proteomic profiling by array (17)
MicroRNA profiling by array (16)
Spatial transcriptomics by high-throughput sequencing (15)
Bisulfite-seq (13)
Cell line - High-throughput sequencing (9)
Ribo-seq (9)
Hi-C (7)
Animal - One-color microarray (6)
MicroRNA profiling by high throughput sequencing (6)
RIP-seq (6)
ChIP-chip by tiling array (5)
Single nucleus RNA sequencing (5)
Transcription profiling by SAGE (4)
MNase-seq (4)

Release Date

2022 (8332)
2021 (7902)
2023 (7484)
2025 (7236)
2024 (6447)
2020 (5965)
2019 (4437)
2018 (4007)
2017 (3649)
2016 (3446)
2015 (3072)
2014 (2602)
2013 (1933)
2012 (1627)
2026 (1531)
2011 (1394)
2010 (1228)
2009 (851)
2008 (629)
2007 (274)
2006 (157)
2005 (140)
2003 (60)
2004 (58)
2001 (37)
2002 (29)
1999 (15)
2000 (11)
1998 (11)
1997 (5)

Location

United States (6)
France (2)
India (1)
China (1)
Japan (1)

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A metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity for the statin class of host-targeted therapeutics

Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it rema...

2019-10-31 | MTBLS846 | MetaboLights

Clinical Applications of Single-Stranded Oligonucleotides: Current Landscape of Approved and In-Development Therapeutics.

Not available

S-EPMC7854307 | biostudies-literature

Deferoxamine as adjunct therapeutics for tuberculosis.

PRJNA1103242 | ENA

Complementary Backbone and Side-chain Analysis of Drug – Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics

Characterizing and distinguishing protein-ligand interactions is crucial for understanding cellular metabolism and guiding drug discovery and development. We employ hydrogen/deuterium exchange mass spectrometry (HDX-MS) and a new Fenton chemistry-based approach to protein oxidative mass spectrometry...

ORGANISM(S): Homo sapiens (Human)

2026-03-27 | PXD050663 | Pride

TGFβ-Directed Therapeutics: 2020.

Not available

S-EPMC7770020 | biostudies-literature

Nguyen2016 - Feedback regulation in cell signalling: Lessons for cancer therapeutics

Feedback regulation in cell signalling: Lessons for cancer therapeutics This model is described in the article: Feedback regulation in cell signalling: Lessons for cancer...

2024-09-02 | BIOMD0000000651 | BioModels

Partitioning of cancer therapeutics in nuclear condensates

PRJNA627353 | ENA

Bile acid therapeutics for NASH

PRJNA705980 | ENA

MicroRNA therapeutics for stratified treatment of Schizophrenia

PRJNA929968 | ENA

Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 Agents.

Not available

S-EPMC9414278 | biostudies-literature