Sort   by:  
 Page size 
ProteomicsComplementary Backbone and Side-chain Analysis of Drug – Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics
Characterizing and distinguishing protein-ligand interactions is crucial for understanding cellular metabolism and guiding drug discovery and development. We employ hydrogen/deuterium exchange mass spectrometry (HDX-MS) and a new Fenton chemistry-based approach to protein oxidative mass spectrometry...
ORGANISM(S): Homo sapiens (Human) 
2026-03-27 | PXD050663 | Pride
Hdx Ox-ms Bcl2 Binding 
ProteomicsStructural Dynamic Impacts of Mosaic SARS-CoV-2 Spike Heterotrimer
Polyvalent vaccines are being widely investigated for their broadening immune responses against rapidly mutating pathogens. In response to the emergence of highly infectious SARS-CoV-2 variants of concern, bivalent mRNA vaccines, which encode the original Hu-1 variant and Omicron variant, have demon...
ORGANISM(S): Homo sapiens (Human) 
2025-09-17 | PXD060785 | Pride
Spike glycoprotein Hdx-ms Sars-cov-2 Antigen display 
TranscriptomicsCD47 modulates the interaction of γ-catenin with E-cadherin and participates in epithelial–mesenchymal transformation in lipid nephrotoxicity
Hyperlipidemia, an important risk factor for cardiovascular diseases and end-stage renal disease, often increases renal injury and compromises kidney function. In the present study, the kidney histology analysis in human samples showed that high lipid levels induced renal fibrosis. However, the mech...
ORGANISM(S): Homo sapiens 
2021-03-10 | GSE161737 | GEO
UnknownIdentification of novel oxidized levuglandin D2 in marine red alga and mouse tissue.
Not available
S-EPMC3220291 | biostudies-literature
UnknownHydrogen/Deuterium Exchange and Protein Oxidative Footprinting with Mass Spectrometry Collectively Discriminate the Binding of Small-Molecule Therapeutics to Bcl-2.
Not available
S-EPMC11887655 | biostudies-literature
UnknownPerturbations of Lipids and Oxidized Phospholipids in Lipoproteins of Patients with Postmenopausal Osteoporosis Evaluated by Asymmetrical Flow Field-Flow Fractionation and Nanoflow UHPLC-ESI-MS/MS.
Not available
S-EPMC7022717 | biostudies-literature
UnknownOverlapping Distribution of Orexin and Endocannabinoid Receptors and Their Functional Interaction in the Brain of Adult Zebrafish.
Not available
S-EPMC6077257 | biostudies-literature
UnknownMicrobial interactions lead to rapid micro-scale successions on model marine particles.
Not available
S-EPMC4915023 | biostudies-literature
UnknownOverexpression of TaNAC2D Displays Opposite Responses to Abiotic Stresses between Seedling and Mature Stage of Transgenic Arabidopsis.
Not available
S-EPMC5120104 | biostudies-literature
UnknownMutation within the transmembrane domain of oxidized low-density lipoprotein receptor 1 influences oxidized low-density lipoprotein-induced signal transduction.
Not available
S-EPMC12174723 | biostudies-literature
Sort   by:  
 Page size