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MetabolomicsIntegrated transcriptome-metabolome analysis reveals attenuated combined toxicity: Antagonistic interactions of three thermal processing contaminants in murine kidney-urine systems

To investigate the toxicological effects after individual or combined sub-chronical exposure to oxidized triacylglycerols, aldehydes, and 3-MCPDE formed during thermal processing of high-fat foods, this study implemented transcriptome-metabolome analysis of renal tissues in Kunming mice, suppleme...

2026-02-25 | MTBLS13934 | MetaboLights
MetabolomicsDecoding Food Chemical Reactivity under Thermal Processing Changes by Untargeted LC-HRMS/MS and Feature-Based Molecular Networking

Method applicability, which involves investigating the impact of processing through a kinetic study, in which molecular networks are compared across different baking times to capture the progression of thermally induced reactions.

2026-09-18 | MTBLS13919 | MetaboLights
MetabolomicsMetabolomics uncovers the dual effects of high-pressure and ultra-shear processing in juice
This study investigated the chemical changes in a blended fruit and vegetable juice induced by innovative food processing technologies - high-pressure processing (HPP; 400 MPa, 40oC) and ultra-shear technology (UST; 400 MPa, 40 and 72 °C) - in comparison to conventional thermal treatments at 40 and ...
2025-06-25 | MTBLS12637 | MetaboLights
MetabolomicsThermal Profiling Maps Multilayered Organization of the Mitochondrial Proteome

Mitochondria execute essential metabolic, biosynthetic, and signaling functions, yet the regulatory principles governing their proteome remain incompletely understood. Here, we develop a thermal proteome profiling (TPP) workflow applied directly to purified mitochondria, enabling systematic analy...

2025-12-08 | MTBLS7386 | MetaboLights
MetabolomicsHaplotype-resolved female and male genomes reveal sex-specific genomic regions and provide insights into thermal stress in Scapharca subcrenata

Integrated analyses of transcriptomic, proteomic and metabolomic data sets consistently highlights the crucial involvement of protein function and retinol metabolism pathways in the heat-resistant strain of S. subcrenata. These findings underscore the significance of these pathways in e...

2024-11-11 | MTBLS11038 | MetaboLights
MetabolomicsImpact of shear stress and moderate electric field on the global metabolic profile of a blended fruit and vegetable juice
This study investigated the impact of moderate electric field (MEF) and shear stress (SS) on the chemical profile of a blended fruit and vegetable juice using untargeted metabolomics. Samples underwent mild thermal treatment, MEF, and a combination of MEF and SS, with subsequent chemical changes ana...
2025-09-30 | MTBLS11719 | MetaboLights
TranscriptomicsExpression data from porcelain crabs following heat or cold stress
Porcelain crabs, Petrolisthes cinctipes, live in the marine intertidal zone and routinely experience thermal stress. Genes involved in heat shock responses are generally upregulated following heat stress, differentially expressed genes are involved in different cellular functions. We used microarra...
ORGANISM(S): Petrolisthes cinctipes 
2009-09-21 | E-GEOD-17361 | biostudies-arrayexpress
ProteomicsA Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling
Benchmarking different LFQ-DIA approaches with traditional TMT-DDA for thermal proteome profiling.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040173 | Pride
Hybrid library Target deconvolution Data-dependent acquisition (dda) Tandem mass tag (tmt) Thermal proteome profiling (tpp) Acute myeloid leukaemia (aml) Spectral library Data-independent acquisition (dia) 
GenomicsImpact of thermal treatment, pulsed electric fields, and high-pressure processing on the transcriptome of Escherichia coli ATCC 8739
Impact of thermal treatment, pulsed electric fields, and high-pressure processing on the transcriptome of Escherichia coli ATCC 8739
PRJNA1192960 | ENA
ProteomicsDe novo mapping of the apicomplexan Ca2+-responsive proteome: temperature range thermal profiling experiment
Apicomplexan parasites cause persistent mortality and morbidity worldwide through diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca2+ signaling pathways have been repurposed in these eukaryotic pathogens to regulate parasite-specific cellular processes governing the transition bet...
ORGANISM(S): Toxoplasma gondii RH 
2022-10-15 | PXD033713 | Pride
Toxoplasma Parasite Calcium signaling Cetsa Tpp Apicomplexan Systems biology Thermal profiling 
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