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ProteomicsHypercoagulability and Inflammatory Markers in a Case of Congenital Thrombotic Thrombocytopenic Purpura Complicated by Fetal Demise
Patients who are diagnosed with thrombotic thrombocytopenic purpura (TTP) during pregnancy are at increased risk of maternal and fetal complications including fetal demise. We present a case of a 32-year-old G3P0 (gravida 3, para 0) who presented at 20 weeks’ gestation with a new diagnosis of congen...
ORGANISM(S): Homo sapiens (Human) 
2023-02-23 | PXD037898 | Pride
Platelets  thrombosis  procoagulant membrane dynamics  inflammatory markers  congenital  thrombotic thrombocytopenic purpura  fetal demise 
TranscriptomicsPervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [PAR-iCLIP]
Precise control of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. Parameters determining the specificity and extent of mRNA degradation within the entire inflammation-associated transcriptome remain incompletely understood. Using transcriptome-wide high...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-63466 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild-type and TTP-deficient fibroblast cell lines to identify TTP mRNA targets
Tristetraprolin (TTP) is a tandem CCCH zinc finger protein that was identified through its rapid induction by mitogens in fibroblasts. Studies of TTP-deficient mice, and cells derived from them, showed that TTP could bind to certain AU-rich elements in mRNAs, leading to increases in the rates of mRN...
ORGANISM(S): Mus musculus 
2008-11-22 | E-GEOD-5324 | biostudies-arrayexpress
TranscriptomicsGenome wide expression in ADAMTS13-deficient thrombotic thrombocytopenic purpura TTP
This study sought correlates of relapse tendency in TTP by examining gene expression profiles in peripheral blood leukocytes from patients with acquired ADAMTS13-deficient TTP in remission and matched healthy controls for global gene expression and autoantibodies. Total RNA was isolated from PAXgene...
ORGANISM(S): Homo sapiens 
2013-03-07 | E-GEOD-36418 | biostudies-arrayexpress
UnknownCaplacizumab use for immune thrombotic thrombocytopenic purpura: the Milan thrombotic thrombocytopenic purpura registry.
Not available
S-EPMC10502422 | biostudies-literature
UnknownThrombotic thrombocytopenic purpura.
Not available
S-EPMC6132833 | biostudies-literature
UnknownThrombotic thrombocytopenic purpura: a Trojan horse of acute leukemia?: a case report.
Not available
S-EPMC12906077 | biostudies-literature
UnknownLong-term Kidney Outcomes in Patients With Acquired Thrombotic Thrombocytopenic Purpura.
Not available
S-EPMC5733749 | biostudies-literature
UnknownFulminant myocarditis in immune-mediated thrombotic thrombocytopenic purpura: A case report.
Not available
S-EPMC12266088 | biostudies-literature
UnknownCurrent concepts in thrombotic thrombocytopenic purpura.
Not available
S-EPMC2426955 | biostudies-literature
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