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MetabolomicsSequential lipidomic, metabolomic, and proteomic analyses of serum, liver, and heart tissue specimens from peroxisomal biogenesis factor 11α knockout mice
Peroxisomes are versatile single membrane-enclosed cytoplasmic organelles, involved in reactive oxygen species (ROS) and lipid metabolism and diverse other metabolic processes. Peroxisomal disorders result from mutations in Pex genes-encoded proteins named peroxins (PEX proteins) and single peroxiso...
2022-02-02 | MTBLS1887 | MetaboLights
MetabolomicsUntargeted Metabolomics Reveals a Mild Impact of Remote Ischemic Conditioning on the Plasma Metabolome and α-Hydroxybutyrate as a Possible Cardioprotective Factor and Biomarker of Tissue Ischemia
Remote ischemic conditioning (RIC) is a maneuver by which short non-lethal ischemic events are applied on distant organs or limbs to reduce ischemia and reperfusion injuries caused by e.g. heart attacks. As RIC can be induced using a simple blood pressure cuff e.g. prior to revascularization, it con...
2016-12-20 | MTBLS414 | MetaboLights
MetabolomicsGut microbiota carcinogen metabolism causes distal tissue tumours

Exposure to environmental pollutants and human microbiome composition are important predisposition factors for tumour development. Similar to drug molecules, pollutants are typically metabolised in the body, which can change their carcinogenic potential and impact tissue distribution through alte...

2024-06-05 | MTBLS3581 | MetaboLights
MetabolomicsAnalysis of colorectal adenocarcinoma tissue samples by DESI mass spectrometry imaging
Ex vivo colorectal adenocarcinoma samples were analysed by desorption electrospray ionisation using an Orbitrap mass spectrometer. The samples were analysed in negative mode over the m/z range 600-1000. Some of the samples presented in this dataset were analysed as part of [1]. The study makes avail...
2016-04-28 | MTBLS289 | MetaboLights
MetabolomicsPhosphatidylcholine in wheat anthers is a susceptibility factor for Fusarium head blight
Fusarium head blight is a devastating wheat disease that initiates at flowering, with anthers as the preferred infection site. However, the anther-derived molecules driving this susceptibility remain elusive. Here, we identify anther-enriched phosphatidylcholine, particularly PC(18:2/18:2) and PC(16...
2026-06-23 | MTBLS14814 | MetaboLights
MetabolomicsEffect of NAC154 transcription factor overexpression on the field grown poplar stem wood metabolome
Several xylem-associated regulatory genes have been identified that control processes associated with wood formation in poplar. Prominent among these are the NAC domain transcription factors (NACs). We evaluated the putative involvement of Populus NAC154, a co-ortholog of the Arabidopsis gene SND2, ...
2015-01-31 | MTBLS119 | MetaboLights
MetabolomicsUntargeted metabolomics analysis of gingival tissue in patients with severe periodontitis
Periodontitis, as a chronic inflammatory condition, its initiating factor is the plaque biofilm. The inflammation starts in the gingival tissue, if left untreated, may progress to severe periodontitis and cause bone and tooth loss. The purpose of this study was to determine the potential metabolic b...
2026-09-08 | MTBLS8357 | MetaboLights
MetabolomicsMetabolic interactions of “catecholamine-cholesterol derivatives” as a potential mechanism for immunomodulation of chicken adipose tissue

In recent years, the immunomodulatory function of adipose tissue has attracted much attention; however, the mechanism of steady-state regulation of the immune microenvironment in adipose tissue remains unclear. Catecholamines (CAs) activate adipocyte surface β3-AR to promote lipid metabolism, and...

2025-07-15 | MTBLS12719 | MetaboLights
MetabolomicsPhosphatidylcholine in wheat anthers is a susceptibility factor for Fusarium head blight

Non-targeted metabolomics was performed to investigate the metabolic differences between fertile and sterile wheat anthers, and to identify anther-derived metabolites that promote Fusarium head blight infection. Wheat anthers (fertile, sterile, and fertile anthers co-cultured with Fusarium gramin...

2026-06-23 | MTBLS14831 | MetaboLights
MetabolomicsImaginal disc growth factor maintains cuticle structure and controls melanization in the spot pattern formation of Bombyx mori

The complex stripes and patterns of insects play key roles in behavior and ecology. However, the fine-scale regulation mechanisms underlying pigment formation and morphological divergence remain largely unelucidated. Here we demonstrated that imaginal disc growth factor (IDGF) maintains cuticle s...

2020-09-20 | MTBLS1825 | MetaboLights
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