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GenomicsTMEM259 alleles modulate respiratory syncytial virus infection and ER-stress-triggered apoptosis
TMEM259 alleles modulate respiratory syncytial virus infection and ER-stress-triggered apoptosis
PRJNA1267071 | ENA
TranscriptomicsTMEM259 alleles modulate respiratory syncytial virus infection and ER-stress-triggered apoptosis
Respiratory syncytial virus (RSV) is a main cause of infant morbidity and mortality. Susceptibility factors for severe RSV bronchiolitis in previously healthy children are unclear. We analyze genetic variants in 5,141 genes involved in virus sensing, interferon (IFN) signaling and effector functions...
ORGANISM(S): Homo sapiens 
2025-06-01 | GSE297985 | GEO
GenomicsNuclear speckles regulate functional programs in cancer (RNA SART1, DDX39A, SARNP, FIBP, TMEM259 kd)
Nuclear speckles regulate functional programs in cancer (RNA SART1, DDX39A, SARNP, FIBP, TMEM259 kd)
PRJNA1122533 | ENA
TranscriptomicsNuclear speckles regulate functional programs in cancer (RNA SART1, DDX39A, SARNP, FIBP, TMEM259 kd)
Nuclear speckles are dynamic nuclear bodies characterized by high local concentrations of RNA binding proteins and specific non-coding RNAs. Although the contents of speckles suggest multifaceted roles in regulating chromatin dynamics and gene expression, the overarching biological function(s) of nu...
ORGANISM(S): Homo sapiens 
2024-09-03 | GSE269570 | GEO
UnknownQuality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.
Not available
S-EPMC7482433 | biostudies-literature
UnknownMembralin Assembles a MAN1B1-VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation.
Not available
S-EPMC12904022 | biostudies-literature
UnknownMeta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states.
Not available
S-EPMC8744676 | biostudies-literature
UnknownBioinformatic analysis of cancer-associated fibroblast related gene signature as a predictive model in clinical outcomes and immune characteristics of gastric cancer.
Not available
S-EPMC9279800 | biostudies-literature
GenomicsCYP51A1TM degradation
Genome-wide CRISPR-Cas9 screen (TKOv3) data on CYP51A1TM degradation
PRJEB37897 | ENA
ProteomicsThe RNF185/Membralin ubiquitin ligase complex is a new ERAD branch involved in the degradation of a distinct subset of integral membrane proteins.
The endoplasmic reticulum-associated degradation (ERAD) pathway is responsible for ubiquitin-mediated quality control of secretory and ER-resident proteins. In the present study, two short-lived ER integral membrane model proteins were used to screen a genome-wide CRISPR-Cas9 library, resulting in t...
ORGANISM(S): Homo sapiens (Human) 
2020-08-03 | PXD018517 | Pride
Endoplasmic reticulum-associated degradation (erad)  e3 ligase rnf185  membralin  tmem259  tmub1  tmub2  ubiquitin 
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