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ProteomicsEXoO-Tn: Tag-n-Map the Tn Antigen in the Human Proteome
Tn antigen (Tn), a single N-acetylgalactosamine (GalNAc) monosaccharide attached to protein Ser and Thr residues, is found on most solid tumors yet rarely detected in adult tissues: featuring it one of the most distinctive signatures of cancers. Although it is prevalent in cancers, Tn-glycosylation ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD014390 | Pride
Tn antigen Glycoproteomics O-galnac Exoo-tn 
TranscriptomicsExpression data from human naïve (TN), stem cell memory (TSCM), central memory (TCM) and effector memory (TEM) CD8+ T cells
An early-differentiated CD8+ memory T cell subset with stem cell-like properties (TSCM) can be identified within the naïve-like T cell population by the expression of CD95/Fas. Based on experiments including exon- and gene-level expression analysis, we provide evidence that this subset of antigen-sp...
ORGANISM(S): Homo sapiens 
2011-07-12 | E-GEOD-23321 | biostudies-arrayexpress
UnknownIdentification of Tn antigen O-GalNAc-expressing glycoproteins in human carcinomas using novel anti-Tn recombinant antibodies.
Not available
S-EPMC7175968 | biostudies-literature
UnknownThe Tn antigen-structural simplicity and biological complexity.
Not available
S-EPMC7159538 | biostudies-literature
ProteomicsSimultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and the Tn Antigen in Human Cancer Cells
Proteins modified with O-GlcNAc and O-GalNAc (the Tn antigen) play critically important roles in many physiological and pathological processes. Comprehensive and site-specific analysis of proteins modified with O-GlcNAc and the Tn antigen advances our understanding of glycoprotein functions and cell...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088088 | MassIVE
UnknownTargeting Tn Antigen Suppresses Aberrant O-Glycosylation-Elicited Metastasis in Breast Cancer.
Not available
S-EPMC11628356 | biostudies-literature
UnknownOverexpression of Tn antigen induces chronic pancreatitis in mice.
Not available
S-EPMC11965491 | biostudies-literature
UnknownTn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer.
Not available
S-EPMC7730766 | biostudies-literature
UnknownTn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation.
Not available
S-EPMC6378212 | biostudies-literature
ProteomicsLarge-scale and Site-specific Mapping of Intact O-glycans on Glycopeptides with IMPa
We employed the newly available IMPa O-glycoprotease from Pseudomonas aeruginosa for O-glycoproteomics analysis of cultured cells and tissues. The glycopeptides were extracted, purified, and conjugated to a solid support before an enzymatic cleavage by IMPa. O-glycopeptides were analyzed by EThcD, w...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-08-28 | PXD037415 | Pride
O-glycoproteomics  impa  vva  rax  tn antigen 
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