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MetabolomicsWe characterize the anti-phage function of a type IV TA system, ShosTA toxin-antitoxin system provides phage defense via DNA damage and repair
Widespread in bacteria and archaea, Toxin-antitoxin (TA) systems have been recently demonstrated to function in phage defense. Here we characterize the anti-phage function of a type IV TA system, ShosTA. Using structural and biochemical approaches, we show that ShosT couples phosphoribosyltransferas...
2025-02-17 | MTBLS11212 | MetaboLights
ProteomicsStaphylococcus aureus toxin-antitoxin system
Type I toxin-antitoxin (TA) systems are widespread genetic modules in bacterial genomes. They express toxic peptides whose overexpression leads to growth arrest or cell death, whereas antitoxins regulate the expression of toxins, acting as labile antisense RNAs. The Staphylococcus aureus (S. aureus)...
ORGANISM(S): Staphylococcus aureus 
2021-07-05 | PXD023449 | Pride
S. aureus  toxin-antitoxin system  proteomics  cell death 
TranscriptomicsExpression profile for BW25113 M-NM-^TmqsRA with deoxycholate stress
MqsR/MqsA is a well-characterized toxin/antitoxin system with several regulatory roles. Deletion of mqsRA reduced growth with deoxycholate stress. Here we performed a microarray to determine the expression profile with and without mqsRA under deoxycholate stress to determine transcriptional regulat...
ORGANISM(S): Escherichia coli BW25113 
2015-01-09 | E-GEOD-59441 | biostudies-arrayexpress
GenomicsGrowth control switch by a DNA damage-inducible toxin-antitoxin system in Caulobacter
Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. However, it is not always clear whether specific targets of orthologous RNAse toxins are responsible f...
ORGANISM(S): Caulobacter crescentus NA1000 
2016-02-17 | E-GEOD-76721 | biostudies-arrayexpress
GenomicsProfiling the intragenic toxicity determinants of the hok/Sok toxin-antitoxin system
Profiling the intragenic toxicity determinants of the hok/Sok toxin-antitoxin system
PRJNA854135 | ENA
GenomicsHigh-throughput suppressor selection of a type I toxin-antitoxin system in Helicobacter pylori
High-throughput suppressor selection of a type I toxin-antitoxin system in Helicobacter pylori
PRJNA497299 | ENA
ProteomicsRegulation of Toxin-Antitoxin System savRS in Staphylococcus aureus Virulence and Host Key Signaling pathway
Staphylococcus aureus is an important pathogen with strong pathogenicity and serious threat to public health. The toxin-antitoxin system is considered to be contributed to the pathogenicity of S. aureus, but the exact pathogenic mechanism remains unknown. Our previous study showed that toxin-antitox...
ORGANISM(S): Mus Musculus 
2024-12-25 | PXD059235 |
GenomicsA novel prophage-encoded type III toxin–antitoxin system
A novel prophage-encoded type III toxin–antitoxin system promotes resistance to phage infection in Streptococcus pyogenes
PRJEB109274 | ENA
ProteomicsProtecomics analysis of toxin-antitoxin system HigBA mutant in P.aeruginosa
Pseudomonas aeruginosa kill the host Drosophila melanogasger very rapidly due to bacteria fitness in vivo. However, mutant of antitoxin HigA has impaired virulence accompanying with loss of fitness. We suppose the free toxin HigB in higA mutant inhibits some proteins production as to be an RNase. To...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2025-09-21 | PXD060361 | Pride
Camp Vfr Pseudomonas aeruginosa Type iv pili Toxin-antitoxin higba 
TranscriptomicsRNA-seq for identifying toxin MazF and MqsR cleavage sites in toxin expression and subsequent recovery cultures of Escherichia coli (mRNA and ncRNA excluding rRNA)
Bacterial toxin-antitoxin systems are thought to help bacteria to reduce their metabolism in various stressful conditions. Many toxins of the bacterial toxin-antitoxin systems are ribonucleases. Such toxins have been mostly viewed as degraders of mRNA, however recently it was demonstrated that they ...
ORGANISM(S): Escherichia coli K-12 
2018-10-11 | E-MTAB-6993 | biostudies-arrayexpress
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