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TranscriptomicsTranscription profiling of human TRAIL-resistant metastatic vs primary TRAIL-sensitive melanoma cells
T1 and G1 are the two melanoma cell lines, established from primary tumor (T1) and lymph node metastases (G1) of a 77 years old male patient. While G1 cells were resistant to TRAIL (TNF-related apoptosis-inducing ligand) mediated cell death, T1 cells exhibited a high dose- and time-dependent sensiti...
ORGANISM(S): Homo sapiens 
2006-01-01 | E-MEXP-247 | biostudies-arrayexpress
TranscriptomicsComparison of Trail+/+ versus Trail-/- splenic NK cells from naïve and LCMV-infected mice
Investigation of the change of the Trail-dependent NK cell transcriptome during short-term (24h) infection with lymphocytic choriomeningitis virus (LCMV). RNA sequencing-based transcriptomics analysis was performed in spleen-isolated (NK1.1+CD3-) NK cells from 3 naïve Trail+/+ mice, 3 naive Trail-/-...
ORGANISM(S): Mus musculus 
2019-08-27 | E-MTAB-7562 | biostudies-arrayexpress
ProteomicsProteomic analysis of TRAIL-induced endogenous RIPK3-dependent necrosome complex
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a well-known inducer of apoptosis via formation of the primary death-inducing signaling complex (TRAIL-DISC) at the level of membrane death receptors (DR4 and DR5) which recruit successively FADD and caspase-8. TRAIL can also induce ...
ORGANISM(S): Colon Homo sapiens (Human) 
2021-03-18 | PXD003383 | Pride
Ripk3-dependent necrosome  disc  mass spectrometry  trail  trim21 
TranscriptomicsAcquired resistance of Jurkat cells to TNF-related apoptosis-inducing ligand (TRAIL)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to be a potent inducer of apoptosis in various cancer cell lines and primary cancer cells. However, in clinical trials administration of recombinant TRAIL or TRAIL death receptor agonists did not show sufficient efficacy ...
ORGANISM(S): Homo sapiens 
2016-06-15 | E-GEOD-38743 | biostudies-arrayexpress
ProteomicsSo_Kinase_Networks_in_TRAIL_induced_apoptosis
This submission consists of the mass spectrometry raw files for the manuscript by So et al. (Kinase Networks in TRAIL induced apoptosis). This submission contains files for the data presented as supplementary tables 5 (interaction network of 104 protein kinases in DLD-1 cells) acquired on a QSTAR E...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-01-09 | MSV000078989 | MassIVE
TranscriptomicsGene expression profile of TRAIL-sensitive and -resistant H460 cells
We generated H460 cells with acquired TRAIL resistance by exposing the parental sentisitve cells to subtoxic concentrations of TRAIL for 6 months. Then we compared the gene expression profile of the sensitive versus the resistant cells. We generated acquired TRAIL-resistant H460 cells from the senti...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-55859 | biostudies-arrayexpress
TranscriptomicsGene expression changes in breast epithelial cells surviving treatment with TRAIL (TNF-Related Apoptosis Inducing Ligand)
In this study, we subjected the phenomenon of fractional killing in a clonal population of TRAIL-sensitive cells to careful analysis. We asked whether cells that survive initial exposure to TRAIL are sensitive or resistant to subsequent treatment with TRAIL or other apoptosis-inducing agents. We ob...
ORGANISM(S): Homo sapiens 
2013-07-15 | E-GEOD-33340 | biostudies-arrayexpress
TranscriptomicsTRAIL/IZI in Melanoma in 2 cell lines A375 and WM1346
parental versus conditioned, IZI versus control
ORGANISM(S): Homo sapiens 
2022-01-12 | E-MTAB-10669 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profile in TRAIL-sensitive and -resistant H460 cells
We generated H460 cells with acquired TRAIL resistance by exposing the parental sentisitve cells to subtoxic concentrations of TRAIL for 6 months. Then we compared the microRNA expression profile in the sensitive versus resistant cells. H460 cells were treated with subtoxic concentrations of TRAIL...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-55821 | biostudies-arrayexpress
TranscriptomicsAcquired resistance of Jurkat cells to TNF-related apoptosis-inducing ligand (TRAIL): a role for histone deacetylase inhibitors as powerful apoptosis sensitizer.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to be a potent inducer of apoptosis in various cancer cell lines and primary cancer cells. However, in clinical trials administration of recombinant TRAIL or TRAIL death receptor agonists did not show sufficient efficacy ...
ORGANISM(S): Homo sapiens 
2016-06-15 | E-GEOD-38745 | biostudies-arrayexpress
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