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TranscriptomicsImpact of aging on cell-to-cell transcriptional variability during immune stimulation
We explored how aging impacts transcriptional dynamics using single-cell RNA-sequencing to profile hundreds of CD4+ T cells from young and old mice from two divergent species. In young animals, immunological challenge drives a conserved transcriptomic switch from highly variable to tightly regulated...
ORGANISM(S): Mus musculus 
2016-07-21 | E-MTAB-4888 | biostudies-arrayexpress
ProteomicsSystematic discovery of potential regulators of transcriptional variability reveals NAP1L1 as a transcriptional stabilizer in mouse ESCs
Embryonic stem cells (ESCs) exhibit gene expression heterogeneity of key pluripotency factors (e.g. Nanog), suggesting functional relevance. To systematically identify potential regulators of transcriptional variability, we integrated single-cell RNA-seq (scRNA-seq) with ChIP-seq datasets in ESCs. O...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-06 | PXD071600 | Pride
Mesc  nap1l1  dppa3  transcriptional variability  pluripotency 
MetabolomicsMulti-Omics and Integrated Network Analyses Reveal New Insights into the Systems Relationships between Metabolites, Structural Genes, and Transcriptional Regulators in Developing Grape Berries (Vitis vinifera L.) Exposed to Water Deficit (Volatile organic compounds; SPME-GC-MS assay)

Grapes are one of the major fruit crops and they are cultivated in many dry environments. This study comprehensively characterizes the metabolic response of grape berries exposed to water deficit at different developmental stages. Increases of proline, branched-chain amino acids, phenylpropanoids...

2021-08-16 | MTBLS982 | MetaboLights
TranscriptomicsRNA-seq of of dermal fibroblasts
Dermal fibroblasts from human, rhesus macaque, mouse and rat, stimulated with dsRNA (poly I:C), interferon and controls.
The innate immune response - the expression programme that is initiated once a pathogen is sensed - is known to be variable among responding cells, as well as to rapidly evolve...
ORGANISM(S): Mus musculus 
2018-07-06 | E-MTAB-5919 | biostudies-arrayexpress
GenomicsSystematic discovery of potential regulators of transcriptional variability reveals NAP1L1 as a transcriptional stabilizer in mouse ESCs
Systematic discovery of potential regulators of transcriptional variability reveals NAP1L1 as a transcriptional stabilizer in mouse ESCs
PRJNA1311037 | ENA
GenomicsSystematic discovery of potential regulators of transcriptional variability reveals NAP1L1 as a transcriptional stabilizer in mouse ESCs [scRNA-seq]
Systematic discovery of potential regulators of transcriptional variability reveals NAP1L1 as a transcriptional stabilizer in mouse ESCs [scRNA-seq]
PRJNA1315030 | ENA
GenomicsImpact of aging on cell-to-cell transcriptional variability during immune stimulation
Impact of aging on cell-to-cell transcriptional variability during immune stimulation
PRJEB14760 | ENA
Transcriptomicssingle-cell RNA-seq of of dermal fibroblasts
Dermal fibroblasts from human, rhesus macaque, mouse and rat, stimulated with dsRNA (poly I:C) in a time course of 0,2,4 and 8 hours, profiled using the Smart-seq2 protocol.
The innate immune response - the expression programme that is initiated once a pathogen is sensed - is known to be variable...
ORGANISM(S): Macaca mulatta 
2018-07-06 | E-MTAB-5920 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Stratagene univeral human reference RNA using different amounts of RNA to investigate array variability
Affymetrix U133 Plus 2.0 arrays were hybridized with varying amounts of starting material to determine whether different measurements of gene expression were observed. Experiment Overall Design: 1 ug, 2, ug, 5, and 10 ug of Stratagene universal human reference RNA was used to setup a series of react...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-3062 | biostudies-arrayexpress
GenomicsCell-to-cell variability in Myc dynamics drives transcriptional heterogeneity in cancer cells
Cell-to-cell heterogeneity is vital for tumor evolution and survival. How cancer cells achieve and exploit this heterogeneity remains an active area of research. Here we identify c-Myc as a highly heterogeneously expressed transcription factor, and an orchestrator of transcriptional and phenotypic d...
EGAS00001007091 | EGA
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