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MetabolomicsCo-analysis of the metabolomics and transcriptomics reveals regulation network of mint pigment and flavone

Mint is considered to have a greater number of phenolic acids, flavonoids, antioxidants and other bioactive components, and is widely used as food, medicine, spices, and flavoring agents. Thus, metabolites composition is an important parameter for assessing the quality of mint. In this study, two...

2025-11-21 | MTBLS13345 | MetaboLights
MetabolomicsTranscriptomics and metabolomics of engineered Synechococcus elongatus during photomixotrophic growth

BACKGROUND: Converting carbon dioxide (CO2) into value-added chemicals using engineered cyanobacteria is a promising strategy to tackle the global warming and energy shortage issues. However, most cyanobacteria are autotrophic and use CO2 as a sole carbon source, which makes it h...

2022-03-21 | MTBLS2825 | MetaboLights
MetabolomicsTranscriptomics and metabolomics datasets of Paris polyphylla var. yunnanensis with different growth years

Paris polyphylla var. yunnanensis is a widely cultivated rhizomatous perennial woody plant known for producing the highly valued steroidal saponins. Steroidal saponins serve as the primary active component and exhibit a variety of pharmacological effects. However, the accumulation of secondary me...

2025-03-13 | MTBLS10683 | MetaboLights
MetabolomicsComparative metabolomics and transcriptomics revealed multiple pathways associated with polymyxin killing in Pseudomonas aeruginosa
Polymyxins are the last-line antibiotics against multidrug-resistant Pseudomonas aeruginosa however, resistance to polymyxins has been increasingly reported. Therefore, understanding the mechanisms of polymyxin activity and resistance is crucial for preserving their clinical usefulness. This study e...
2018-11-14 | MTBLS751 | MetaboLights
MetabolomicsIntegrated Metabolomics and Transcriptomics Analyses Reveal Anthocyanin and Carotenoid Biosynthesis Involved in Color Development in Willow Bark

Shrub willow has strong adaptability, large biomass and short rotation period. Colorful willow barks have great ornamental and economic value. To study the color regulation mechanism, metabolomics and transcriptomics were used to analyze the purple, green and red barks. In the positive mode, a to...

2022-08-10 | MTBLS4820 | MetaboLights
MetabolomicsCombined metabolomics with transcriptomics reveals important serum biomarkers correlated with lung cancer proliferation through calcium signaling pathway

Lung cancer (LC) is still one of the most deadly cancers in the world, but there is a lack of non-invasive biomarkers to assist diagnosis and guide treatment. Herein, untargeted serum metabolomics of 57 LC patients and 59 HC people was performed based on gas chromatography-mass spectrography (GC-...

2025-04-29 | MTBLS1517 | MetaboLights
MetabolomicsIntegrated Metabolomics, Transcriptomics, and Functional Validation Reveal Oxidoreductase-Associated Strictinin Accumulation in Assam tea Germplasm
Strictinin, a bioactive hydrolyzable tannin in tea, accumulates at high levels in some Assam tea germplasms, yet the molecular basis underlying its variation remains unclear. Here, a rapid LC-MS/MS method was established for strictinin quantification and applied to profile 157 Assam tea accessions, ...
2026-08-03 | MTBLS14896 | MetaboLights
MetabolomicsMetabolo-transcriptomics analyses reveal alfalfa adaptation to combined saline-alkali and low-temperature stress in the field

Metabolomics analysis revealed specific accumulation of amino acids, organic acids, carbohydrates, fatty acids and flavonoids in ZD compared with that in BM. The core differential metabolites associated with ZD stress resistance included isoleucine, fumaric acid, raffinose and isovitexin. In...

2025-06-19 | MTBLS12611 | MetaboLights
MetabolomicsIntegrated metabolomics and transcriptomics analysis elucidate the candidate genes for polyphyllin biosynthesis in Paris

Polyphyllins are the key components in Paris, with varying levels and compositions among different species. This study investigated polyphyllin compositions of 206 Paris samples from 16 different producing areas. 9 Paris polyphylla var. yunnanensis, 3 Paris fargesii and 3 Paris forrestii were sel...

2024-10-18 | MTBLS10682 | MetaboLights
MetabolomicsIntegration of metabolomics and transcriptomics reveals major metabolic pathways and potential biomarkers involved in pulmonary tuberculosis and pulmonary tuberculosis-complicated diabetes

Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are common chronic diseases that threaten human health. Patients with DM are susceptible to PTB, an important factor that aggravates the complications of diabetes. However, the molecular regulatory mechanism underlying the susceptibility of ...

2023-07-26 | MTBLS7623 | MetaboLights
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