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ProteomicsRac1 inhibition prevents cytoskeleton dysfunction and axonal degeneration in Transthyretin Amyloid Polyneuropathy
Transthyretin Amyloid Polyneuropathy (ATTR-PN) is characterized by the deposition of amyloidogenic TTR particularly in dorsal root ganglia (DRG) and peripheral nerve axons leading to a sensory axonopathy. Here, we investigated the role of cytoskeleton alterations in peripheral axons from an ATTR-PN ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-10 | PXD054291 | Pride
Transthyretin  axonopathy  transthyretin amyloid polyneuropathy  cytoskeleton  microtubule dynamics  actin  axonal transport  peripheral nervous system  rac1 
TranscriptomicsA Gene Expression-based Blood Diagnostic for Symptomatic Transthyretin Amyloidosis Revealing Male and Female-specific Signatures
Early diagnosis of transthyretin (TTR) amyloid diseases remains challenging because of variable disease penetrance. Currently, patients must have an amyloid positive tissue biopsy to be eligible for disease modifying therapies. Early diagnosis is often difficult because the patient exhibits apparent...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-67784 | biostudies-arrayexpress
UnknownTransthyretin familial amyloid polyneuropathy (TTR-FAP): Parameters for early diagnosis.
Not available
S-EPMC5853640 | biostudies-literature
UnknownEarly intervention with tafamidis provides long-term (5.5-year) delay of neurologic progression in transthyretin hereditary amyloid polyneuropathy.
Not available
S-EPMC5359776 | biostudies-literature
UnknownRepurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer.
Not available
S-EPMC7583827 | biostudies-literature
UnknownTransthyretin interacts with actin regulators in a Drosophila model of familial amyloid polyneuropathy.
Not available
S-EPMC7423984 | biostudies-literature
UnknownClinical and genetic analysis of a family with transthyretin amyloid polyneuropathy caused by a TTR Lys55Asn mutation.
Not available
S-EPMC12817533 | biostudies-literature
UnknownFirst European consensus for diagnosis, management, and treatment of transthyretin familial amyloid polyneuropathy.
Not available
S-EPMC4739312 | biostudies-literature
UnknownFeasibility of assessing progression of transthyretin amyloid polyneuropathy using nerve conduction studies: Findings from the Transthyretin Amyloidosis Outcomes Survey (THAOS).
Not available
S-EPMC8360174 | biostudies-literature
UnknownTafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial.
Not available
S-EPMC4098875 | biostudies-literature
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