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ProteomicsIs transthyretin a regulator of Ubc9 SUMOylation?
Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR. Because protein structure is regulated through posttranslational modifications, we investigated the Small Ubiquitin-like Modifier (SUMO)ylatio...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080754 | MassIVE
TranscriptomicsTranscription profiling of mouse vehicle and sAPPalpha-treated hippocampal slice cultures
Gene expression changes induced by alpha-secretase cleaved amyloid precursor protein (sAPPalpha) in organotypic hippocampal slice cultures of male, postnatal day 15 mice (C57B6/SJL). Hippocampal slice cultures were treated with phosphate buffered saline (GSM26700, GSM26701, GSM26702) or 1 nM sAPPal...
ORGANISM(S): Mus musculus 
2007-10-10 | E-GEOD-1555 | biostudies-arrayexpress
ProteomicsRac1 inhibition prevents cytoskeleton dysfunction and axonal degeneration in Transthyretin Amyloid Polyneuropathy
Transthyretin Amyloid Polyneuropathy (ATTR-PN) is characterized by the deposition of amyloidogenic TTR particularly in dorsal root ganglia (DRG) and peripheral nerve axons leading to a sensory axonopathy. Here, we investigated the role of cytoskeleton alterations in peripheral axons from an ATTR-PN ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-10 | PXD054291 | Pride
Transthyretin  axonopathy  transthyretin amyloid polyneuropathy  cytoskeleton  microtubule dynamics  actin  axonal transport  peripheral nervous system  rac1 
ProteomicsPlasmin activity promotes amyloid deposition in a new transgenic model of human transthyretin amyloidosis.
We have developed a new mouse model of transthyretin (TTR) amyloidosis using transgenic mice expressing the most fibrillogenic variant of TTR (S52P). Following seeding with amyloid fibrils, TTR amyloid is deposited mainly in the heart and tongue. The fibrils contain both full length and truncated ...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-27 | PXD027747 | Pride
Transthyretin Heart Mouse Amyloidosis Tongue 
GenomicsPrevalence of transthyretin amyloidosis in patients with heart failure and no left ventricular hypertrophy
The study prospectively enrolled patients admitted for HF with LV ejection fraction (LVEF) ≥ 50% and LV wall thickness <12 mm. TTR cardiac amyloidosis was diagnosed according to accepted criteria, which include positive cardiac 99-Tc-DPD scintigraphy in the absence of monoclonal protein expansi...
EGAS00001005398 | EGA
ProteomicsIs transthyretin a regulator of Ubc9 SUMOylation?
Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR. Because protein structure is regulated through posttranslational modifications, we investigated the Small Ubiquitin-like Modifier (SUMO)ylatio...
ORGANISM(S): Homo sapiens (Human) 
2016-08-15 | PXD004515 | Pride
Post-translational modifications Sumoylation Transthyretin Ubc9 Ufds 
TranscriptomicsA Gene Expression-based Blood Diagnostic for Symptomatic Transthyretin Amyloidosis Revealing Male and Female-specific Signatures
Early diagnosis of transthyretin (TTR) amyloid diseases remains challenging because of variable disease penetrance. Currently, patients must have an amyloid positive tissue biopsy to be eligible for disease modifying therapies. Early diagnosis is often difficult because the patient exhibits apparent...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-67784 | biostudies-arrayexpress
GenomicsTransthyretin orchestrates vitamin B12-induced stress resilience
Transthyretin orchestrates vitamin B12-induced stress resilience
PRJNA1109405 | ENA
GenomicsCirculating microRNAs profile in patients with transthyretin variant amyloidosis
Circulating microRNAs profile in patients with transthyretin variant amyloidosis
PRJNA629572 | ENA
GenomicsTransthyretin alters cardiac fibroblast structure, function and inflammatory gene expression.
Transthyretin alters cardiac fibroblast structure, function and inflammatory gene expression.
PRJNA734300 | ENA
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