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ProteomicsIs transthyretin a regulator of Ubc9 SUMOylation?
Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR. Because protein structure is regulated through posttranslational modifications, we investigated the Small Ubiquitin-like Modifier (SUMO)ylatio...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080754 | MassIVE
ProteomicsAuto-sumoylation of the Ubc9 E2 SUMO-conjugating Enzyme Extends Cellular Lifespan
Calorie restriction (CR) provides anti-aging benefits through diverse processes, such as reduced metabolism and growth and increased mitochondrial activity. Although controversy still exists regarding CR-mediated lifespan effects, many researchers are seeking interventions that mimic the effects of ...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2025-01-15 | PXD048944 | Pride
Sumo Ubc9. lifespan 
ProteomicsIs transthyretin a regulator of Ubc9 SUMOylation?
Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR. Because protein structure is regulated through posttranslational modifications, we investigated the Small Ubiquitin-like Modifier (SUMO)ylatio...
ORGANISM(S): Homo sapiens (Human) 
2016-08-15 | PXD004515 | Pride
Post-translational modifications Sumoylation Transthyretin Ubc9 Ufds 
TranscriptomicsSumoylation-deficient bone marrow derived dendritic cells transcriptomic analysis after LPS stimulation
Bone marrow derived dendritic cells were generated from Ubc9[fl;-] and Ubc9[+/+] mice. After in vitro derivation in the presence of GM-CSF, dendritic cells were treated with tamoxifen for four days to cause CreERT2 activation, and induce Ubc9 floxed allele deletion. This allowed comparative transcri...
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-66178 | biostudies-arrayexpress
GenomicsUBC9 knockdown in bladder cancer T24 cell lines
UBC9 knockdown in bladder cancer T24 cell lines
PRJNA481271 | ENA
GenomicsExpression data from FACS-purified Lgr5-EGFP+ intestinal cells from Ubc9+/+ and Ubc9+/- mice
Expression data from FACS-purified Lgr5-EGFP+ intestinal cells from Ubc9+/+ and Ubc9+/- mice
PRJNA609313 | ENA
ProteomicsAuto-sumoylation of the Ubc9 E2 SUMO-conjugating Enzyme Extends Cellular Lifespan
Calorie restriction (CR) provides anti-aging benefits through diverse processes, such as reduced metabolism and growth and increased mitochondrial activity. Although controversy still exists regarding CR-mediated lifespan effects, many researchers are seeking interventions that mimic the effects of ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-01-15 | PXD049427 | Pride
Lc ms/ms Sumo  ubc9  lifespan  energy metabolism  calorie restriction 
TranscriptomicsUBC9 knockdown in bladder cancer T24 cell lines
UBC9 is the sole conjugating enzyme E2 in the sumoylation and plays a pivotal role in maintaining homeostasis and restraining stress reaction. Targeting UBC9 is emerging as a novel strategy for cancer therapy. However, the role of UBC9 in bladder cancer is not clear. Here, we sought to determine the...
ORGANISM(S): Homo sapiens 
2018-12-25 | GSE117143 | GEO
GenomicsExpression data of intestinal polyps and intestinal normal tissue from Ubc9+/+ and Ubc9+/- Villin-CreERT2 Apcf/+ mice 12 weeks after 4-OHT treatment
Expression data of intestinal polyps and intestinal normal tissue from Ubc9+/+ and Ubc9+/- Villin-CreERT2 Apcf/+ mice 12 weeks after 4-OHT treatment
PRJNA609109 | ENA
UnknownIs Transthyretin a Regulator of Ubc9 SUMOylation?
Not available
S-EPMC4976990 | biostudies-literature
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