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MetabolomicsDisruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Mouse Model of Amyloidosis
Alzheimer’s disease (AD) is characterized by a prolonged asymptomatic phase before cognitive decline emerges, yet the mechanisms driving symptom onset remain unclear. Here, we hypothesized that the transition from asymptomatic to symptomatic disease is linked to dysfunction of brain–immune communica...
2026-06-01 | MTBLS14615 | MetaboLights
TranscriptomicsPhenotypic, transcriptomic and genomic characterization of clonal plasma cells in light chain amyloidosis [Copy number analysis]
Immunoglobulin light-chain amyloidosis (AL) is a rare clonal plasma cell (PC) disorder that remains largely incurable. AL and multiple myeloma (MM) share the same cellular origin, but while knowledge about MM PC biology has improved significantly, the same does not apply for AL. Here, we undertook a...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-73041 | biostudies-arrayexpress
TranscriptomicsPhenotypic, transcriptomic and genomic characterization of clonal plasma cells in light chain amyloidosis [Gene expression profiling]
Immunoglobulin light-chain amyloidosis (AL) is a rare clonal plasma cell (PC) disorder that remains largely incurable. AL and multiple myeloma (MM) share the same cellular origin, but while knowledge about MM PC biology has improved significantly, the same does not apply for AL. Here, we undertook a...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-73040 | biostudies-arrayexpress
UnknownLight Chain Amyloidosis: Patient Experience Survey from the Amyloidosis Research Consortium.
Not available
S-EPMC4635176 | biostudies-literature
ProteomicsPlasmin activity promotes amyloid deposition in a new transgenic model of human transthyretin amyloidosis.
We have developed a new mouse model of transthyretin (TTR) amyloidosis using transgenic mice expressing the most fibrillogenic variant of TTR (S52P). Following seeding with amyloid fibrils, TTR amyloid is deposited mainly in the heart and tongue. The fibrils contain both full length and truncated ...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-27 | PXD027747 | Pride
Transthyretin Heart Mouse Amyloidosis Tongue 
UnknownIn vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis.
Not available
S-EPMC5580339 | biostudies-literature
UnknownThe Amyloidosis Forum: a public private partnership to advance drug development in AL amyloidosis.
Not available
S-EPMC7523334 | biostudies-literature
TranscriptomicsPhenotypic, transcriptomic and genomic characterization of clonal plasma cells in light chain amyloidosis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-73042 | biostudies-arrayexpress
ProteomicsMatrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging: a novel Tool for the Identification and Classification of Amyloidosis
Amyloidosis is a group of diseases caused by extracellular accumulation of fibrillar polypeptide aggregates. So far, diagnosis is performed by Congo red staining of tissue sections in combination with polarization microscopy. Subsequent identification of the causative protein by immunohistochemistry...
ORGANISM(S): Homo sapiens (Human) 
2017-10-16 | PXD005960 | Pride
Formalin-fixed and paraffin-embedded Amyloidosis Ion mobility separation Maldi ms imaging 
UnknownPeripheral Nervous, Hepatic, and Gastrointestinal Endpoints for AL Amyloidosis Clinical Trials: Report from the Amyloidosis Forum Multi-organ System Working Group.
Not available
S-EPMC10567953 | biostudies-literature
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