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MetabolomicsMicrobiome and Metabolome Integrated Analysis: Exploring Potential Diagnostic Approaches for Parkinson’s Disease Using Tongue Coating Samples

Parkinson's disease (PD) is a prevalent neurodegenerative disorder with complex pathogenesis and limited treatment options. The current reliance on clinical evaluation for diagnosis, due to the absence of reliable non-invasive methods, presents significant challenges. Traditional diagnostic appro...

2025-07-05 | MTBLS12679 | MetaboLights
TranscriptomicsOral tongue cancer gene expression profiling: Identification of novel potential prognosticators
Background: The present study is aimed at identifying potential candidate genes as prognostic markers in human oral tongue squamous cell carcinoma (SCC) by large scale gene expression profiling. Methods: The gene expression profile of patients (n=37) with oral tongue SCC were analyzed using Affyme...
ORGANISM(S): Homo sapiens 
2008-11-14 | E-GEOD-13601 | biostudies-arrayexpress
ProteomicsMetaproteomics Analysis of Microbial Diversity of Human Saliva and Tongue Dorsum in Young Healthy Individuals
dataset for metaproteomics analysis to characterize of the composition of salivary and tongue microbial communities within healthy subjects in the range of age between 20-30 years
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-26 | MSV000084137 | MassIVE
ProteomicsProteomic analysis of the mouse tongue proteome in response to western diet
The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization and swallowing. The surface of the tongue is lined with papillae which contain gustatory cells expressing various taste receptors. There is growing evidence to suggest our perceptions of ...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD025190 | Pride
Metabolism Proteomics Obesity Tongue Taste 
TranscriptomicsGene expression profiling of archival tongue carcinoma and normal tongue tissue
This SuperSeries is composed of the following subset Series: GSE34105: Gene expression profiling of archival tongue carcinoma and normal tongue tissue (all samples) GSE34106: Gene expression profiling of archival tongue carcinoma and normal tongue tissue (subset) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-05-10 | E-GEOD-34115 | biostudies-arrayexpress
TranscriptomicsHSC-3 cells (control) vs. HSC-3-5 cells [tongue]
HSC-3-5 cells, which drived from human HSC-3 cells via transwell invasion assay was high invasive.Tumor cells were injected into the tongue of SCID mice. After 1 week, transcriptional profiling of human HSC-3 tumor comparing with high invasive HSC-3-5 tumor. Goal was to determine the effects of inv...
ORGANISM(S): Homo sapiens 
2013-08-13 | E-GEOD-39725 | biostudies-arrayexpress
TranscriptomicsRNAseq comparison of gene expression profiles in Osr1 mutant and control mouse embryonic tongue
The tongue is a muscular organ in the vertebrate oral cavity that performs complex functions in daily life, including feeding and phonetic articulation. The tongue consists of mesenchyme cells of two distinct origins: the muscle cells are derived from occipital somites whereas the tendons and other ...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-45893 | biostudies-arrayexpress
ProteomicsIntegrated proteomics and phosphoproteomics revealed druggable kinases in neoadjuvant chemotherapy resistant tongue cancer
Tongue squamous cell carcinoma is characterised by poor prognosis and high metastatic events. Patients with unresectable tumors are benefiting from neoadjuvant chemotherapy (NACT) which surgical resection, and controls distant metastasis, and locoregional recurrence. However, resistance to NACT limi...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037356 | Pride
Human Lc-msms Tissue Tongue 
TranscriptomicsGene expression profiling of Myf5-Cre;Smad4flox/flox mouse models of tongue development
We investigated Smad4-mediated TGF-beta signaling in the development of occipital somite-derived myogenic progenitors during tongue morphogenesis by comparing the transcriptomes of tongue derived from Myf5-Cre;Smad4flox/flox mutant and Myf5-Cre;Smad4flox/+ control mice at day E13.5. Based on gene ex...
ORGANISM(S): Mus musculus 
2012-02-03 | E-GEOD-35357 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of archival tongue carcinoma and normal tongue tissue (subset)
RNA extracted from 78 FFPE tongue samples, 62 tongue carcinomas and 16 non-malignant controls, were succesfully analysed using the whole genome DASL array to obtain gene expression profiles. Gene expression profiles were used to identify differentially expressed genes with the ultimate goal of findi...
ORGANISM(S): Homo sapiens 
2012-05-10 | E-GEOD-34106 | biostudies-arrayexpress
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