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MetabolomicsMitochondrial NAD+ Deficiency in Vascular Smooth Muscle Impairs Collagen III Turnover to Trigger Aortic Disease

Aortic disease poses a significant mortality risk in adults, yet many of its underlying factors remain undiscovered. In this study, we identify mitochondrial NAD⁺ deficiency as a causal factor. Metabolomics analysis of 73 surgical aortic specimens revealed impaired NAD⁺ salvage and mitochondrial ...

2024-12-04 | MTBLS8062 | MetaboLights
ProteomicsXL-MS data of trigger factor and GAPDH binding
We present XL-MS data of the trigger factor:GAPDH complex to define the interaction sites for GAPDH on trigger factor.
ORGANISM(S): Escherichia coli 
2022-06-07 | PXD029365 | Pride
Chaperone  trigger factor  gapdh  folding 
ProteomicsHDX-MS data of trigger factor and GAPDH binding
We present HDX-MS data of the trigger factor:GAPDH complex to define the interaction sites for GAPDH on trigger factor and the structure of GAPDH in the bound state.
ORGANISM(S): Escherichia coli 
2022-06-07 | PXD029364 | Pride
Chaperone  trigger factor  gapdh  folding 
TranscriptomicsSelective ribosome profiling reveals the co-translational chaperone action of trigger factor in vivo
As nascent polypeptides exit ribosomes, they are engaged by a series of processing, targeting and folding factors. Here we present a selective ribosome profiling strategy that enables global monitoring of when these factors engage polypeptides in the complex cellular environment. Studies of the Esch...
ORGANISM(S): Escherichia coli 
2011-12-09 | E-GEOD-33671 | biostudies-arrayexpress
ProteomicsUnexpected role of a truncated ribosome-associated chloroplast trigger factor homolog serving ribosome biogenesis in plants - Data set 1 (Global proteome of wt and tig2 mutants)
Molecular chaperones are essential throughout a protein's life and act already during protein synthesis. Bacteria and chloroplasts of plant cells share the ribosome-associated chaperone trigger factor (Tig1 in plastids), facilitating maturation of emerging nascent polypeptides. While typical trigger...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-03-11 | PXD052583 | Pride
Trigger factor Ribosome Arabidopsis 
ProteomicsUnexpected role of a truncated ribosome-associated chloroplast trigger factor homolog serving ribosome biogenesis in plants - Data set 2: Analysis of sedimented ribosomes
Molecular chaperones are essential throughout a protein's life and act already during protein synthesis. Bacteria and chloroplasts of plant cells share the ribosome-associated chaperone trigger factor (Tig1 in plastids), facilitating maturation of emerging nascent polypeptides. While typical trigger...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-03-11 | PXD052586 | Pride
Trigger factor Ribosome Arabidopsis Chloroplast 
ProteomicsResolving chaperone-assisted protein folding on the ribosome at the peptide level
The cellular environment is critical for efficient protein maturation, but how proteins fold during biogenesis remains poorly understood. We used hydrogen/deuterium exchange (HDX) mass spectrometry (MS) to define, at peptide resolution, the cotranslational chaperone-assisted folding pathway of Esche...
ORGANISM(S): Escherichia coli 
2024-07-12 | PXD036945 | Pride
Hdxms  hydrogen deuterium exchange mass spectrometry  protein folding  chaperone  ribosome  trigger factor  dhfr  cotranslational folding 
ProteomicsStaphylococcus aureus Trigger factor is involved in biofilm formation and cooperates with the chaperone PpiB
Peptidyl-prolyl cis/trans isomerases (PPIases) are enzymes that assist in protein folding around proline-peptide bonds, and often possess chaperone activity. Staphylococcus aureus encodes three PPIases; PrsA, PpiB and Trigger factor (TF). Previous work by our group demonstrated a role for both PrsA ...
ORGANISM(S): Staphylococcus aureus 
2021-01-28 | PXD023811 | Pride
Virulence Fk506 binding proteins Cyclophilins Trigger factor Staphylococcus aureus 
TranscriptomicsAn Ancient Transcription Factor Initiates the Burst of piRNA Production During Early Meiosis in Mouse Testes (RNA-Seq)
Animal germ cells produce PIWI-interacting RNAs (piRNAs), small silencing RNAs that suppress transposons and enable gamete maturation. Mammalian transposon-silencing piRNAs accumulate early in spermatogenesis, whereas pachytene piRNAs are produced later during post-natal spermatogenesis and account ...
ORGANISM(S): Mus musculus 
2013-03-26 | E-GEOD-44654 | biostudies-arrayexpress
TranscriptomicsAn Ancient Transcription Factor An Ancient Transcription Factor During Early Meiosis in Mouse Testes (PAS-Seq and CAGE)
Animal germ cells produce PIWI-interacting RNAs (piRNAs), small silencing RNAs that suppress transposons and enable gamete maturation. Mammalian transposon-silencing piRNAs accumulate early in spermatogenesis, whereas pachytene piRNAs are produced later during post-natal spermatogenesis and account ...
ORGANISM(S): Mus musculus 
2013-03-27 | E-GEOD-45048 | biostudies-arrayexpress
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