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ProteomicsTRIM9 and TRIM67 interactome using the BioID approach
TRIM9 and TRIM67 are two brain enriched E3 uiquitin ligases that are critical to neuronal form and function both during embryonic development and in adult-born neurons. TRIM9 and TRIM67 interact with cytoskeletal and exocytic proteins, but the full interactome is not known.Using the BioID approach w...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD021758 | Pride
Embryonic cortical neurons Orbitrap fusion lumos 
ProteomicsLoss of the E3 ubiquitin ligase Trim9 or Trim67 alters the post-synaptic density proteome
During development, neurons undergo expansive growth and shape change to achieve their mature morphology and physiological function. As cellular remodeling occurs, proteins are synthesized, transported, degraded, and recycled. As such, protein levels and localization are tightly regulated. E3 ubiqui...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-17 | PXD048045 | Pride
Synapse  post-synaptic density  trim9  trim67  e3 ubiquitin ligase 
GenomicsTRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
PRJNA765042 | ENA
TranscriptomicsTRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
The aim of this study is to characterize the mechanistic role of TRIM67 in glioma biogenesis. Towards this goal, here we utilized engineered human neural stem cells and patient-derived tumor sphere lines with or without IDH mutations and 1p/19q co-deletions to study the function of TRIM67 in gliomas...
ORGANISM(S): Homo sapiens 
2022-09-21 | GSE184567 | GEO
UnknownCoro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis.
Not available
S-EPMC12614643 | biostudies-literature
UnknownTRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing.
Not available
S-EPMC10237422 | biostudies-literature
UnknownLoss of the E3 ubiquitin ligase TRIM67 alters the post-synaptic density proteome.
Not available
S-EPMC10802379 | biostudies-literature
UnknownLoss of the E3 ubiquitin ligase TRIM67 alters the post-synaptic density proteome.
Not available
S-EPMC10943362 | biostudies-literature
UnknownThe TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.
Not available
S-EPMC8098814 | biostudies-literature
UnknownTRIM67 Suppresses TNFalpha-Triggered NF-kB Activation by Competitively Binding Beta-TrCP to IkBa.
Not available
S-EPMC8901487 | biostudies-literature
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