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TranscriptomicsThe Translin-TRAX complex/C3PO is a ribonuclease in tRNA processing
The endogenous RNA substrates of Translin-TRAX complexes (also known as C3POs) and how they regulate diverse biological processes remain unknown. Here we show that Translin and TRAX do not play a significant role in RNAi in the filamentous fungus Neurospora crassa. Instead, the Neurospora C3PO compl...
ORGANISM(S): Neurospora crassa 
2012-07-30 | E-GEOD-38334 | biostudies-arrayexpress
TranscriptomicsA growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo
Argonaute/Piwi proteins associate with small RNAs that typically provide sequence specificity for RNP function in gene and genome regulation. Here we show that Twi12, a Tetrahymena Piwi protein essential for growth, is loaded with mature tRNA fragments. The tightly bound ~18-22 nt tRNA 3M-bM-^@M-^Y ...
ORGANISM(S): Tetrahymena thermophila 
2010-10-26 | E-GEOD-24916 | biostudies-arrayexpress
ProteomicsMolecular architecture of the tRNA ligase complex
In human cells, a subset of tRNA-encoding genes contain introns. These are removed by a non-canonical splicing pathway in which the tRNA splicing endonuclease complex catalyzes intron excision and the resulting exons are subsequently ligated by the tRNA-ligase complex (tRNA-LC). The tRNA-LC is a het...
ORGANISM(S): Homo sapiens (Human) 
2026-08-04 | PXD068427 | Pride
Human Trna Rna Protein complex 
TranscriptomicstRNA fragment profiling in CLP1 mutant (kinase-dead) mice
Loss of CLP1 activity results in the accumulation of novel sets of small RNA fragments derived from aberrant processing of tyrosine pre-tRNA. Such tRNA fragments sensitize cells to oxidative stress-induced p53 activation and p53-dependent cell death. 2 samples, Wt and Clp1(k/k), no replicates
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-39275 | biostudies-arrayexpress
ProteomicsMolecular architecture of the human tRNA ligase complex
Chemical cross-linking coupled to mass spectrometry was used to study two tRNA ligase complexes, one consisting of subunits RTCB, DDX1, CGI-99, FAM98B and Ashwin (“full tRLC”) and one lacking Ashwin (“core tRLC”). Cross-linking was performed using the homobifunctional, noncleavable reagent, disuccin...
ORGANISM(S): Homo sapiens (Human) 
2021-12-15 | PXD025662 | Pride
Chemical cross-linking  dss  structural proteomics  protein complex  trna ligase complex 
GenomicsRTP801 INTERACTS WITH THE tRNA LIGASE COMPLEX AND DYSREGULATES ITS RNA LIGASE ACTIVITY IN ALZHEIMER’S DISEASE
RTP801 INTERACTS WITH THE tRNA LIGASE COMPLEX AND DYSREGULATES ITS RNA LIGASE ACTIVITY IN ALZHEIMER’S DISEASE
PRJNA1111774 | ENA
GenomicsOTTR-seq of FXTAS brain reveals tRNA ligase dysfunction
OTTR-seq of FXTAS brain reveals tRNA ligase dysfunction
PRJNA1195357 | ENA
UnknownMolecular architecture of the human tRNA ligase complex.
Not available
S-EPMC8668186 | biostudies-literature
OtherRTP801 INTERACTS WITH THE tRNA LIGASE COMPLEX AND DYSREGULATES ITS RNA LIGASE ACTIVITY IN ALZHEIMER’S DISEASE
RTP801/REDD1 is a stress-responsive protein overexpressed in neurodegenerative diseases such as Alzheimer’s disease (AD) that contributes to cognitive deficits and neuroinflammation. Here we found that RTP801 interacts with HSPC117, DDX1, and CGI-99, three members of the tRNA ligase complex (tRNA-LC...
ORGANISM(S): Mus musculus 
2024-09-12 | GSE267524 | GEO
TranscriptomicsSmall tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C
Small, non-coding RNAs control gene expression post-transcriptionally and play important roles in virus-host interactions. Within the liver, the microRNA (miRNA) miR-122 is essential for replication of hepatitis C virus (HCV), while repression of miR-148a by hepatitis B virus (HBV) may enhance tumor...
ORGANISM(S): Homo sapiens 
2014-12-18 | E-GEOD-57381 | biostudies-arrayexpress
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