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TranscriptomicsKMT1E Mediated H3K9 Methylation Is Required for the Maintenance of Embryonic Stem Cells by Repressing Trophectoderm Differentiation
Dynamic regulation of histone methylation by methyltransferases and demethylases plays a central role in regulating the fate of embryonic stem (ES) cells. The histone H3K9 methyltransferase KMT1E, formerly known as ESET or Setdb1, is essential to embryonic development as the ablation of the Setdb1 g...
ORGANISM(S): Mus musculus 
2011-04-15 | E-GEOD-28593 | biostudies-arrayexpress
TranscriptomicsComparison of the transcriptome of day 3 human embryo with that of the trophectoderm
In humans, the embryonic genome activation (EGA) program is functional by day 3 after fertilization. The 6-8 cell stage embryo (day 3 post-fertilization) starts the process of “compaction” that leads to the generation of the tightly organized cell mass of the morula and is followed by differentiatio...
ORGANISM(S): Homo sapiens 
2012-07-08 | E-GEOD-33025 | biostudies-arrayexpress
GenomicsDevelopment of an improved in vitro model of bovine trophectoderm differentiation
Development of an improved in vitro model of bovine trophectoderm differentiation
PRJNA823685 | ENA
GenomicsMouse morula-derived trophectoderm stem cell organoids
Mouse morula-derived trophectoderm stem cell organoids Transcriptome
PRJNA1092531 | ENA
GenomicsMouse morula-derived trophectoderm stem cell organoids
Mouse morula-derived trophectoderm stem cell organoids Transcriptome
PRJNA1092430 | ENA
GenomicsPRC2 shields naive pluripotent cells from trophectoderm and mesoderm differentiation [ChIP-seq]
PRC2 shields naive pluripotent cells from trophectoderm and mesoderm differentiation [ChIP-seq]
PRJNA751100 | ENA
GenomicsPRC2 shields naive pluripotent cells from trophectoderm and mesoderm differentiation [RNA-seq]
PRC2 shields naive pluripotent cells from trophectoderm and mesoderm differentiation [RNA-seq]
PRJNA751101 | ENA
UnknownPolycomb repressive complex 2 shields naive human pluripotent cells from trophectoderm differentiation.
Not available
S-EPMC9203276 | biostudies-literature
ProteomicsA Simple Human Embryo Model Reveals V-ATPase Requirement in Mammalian Blastocyst Cavitation
Human naïve pluripotent stem cells (nPSCs) can differentiate into trophectoderm (TE) and self-organize into embryo-like structures known as blastoids, typically requiring complex cocktails of signaling factors. Here, we demonstrate that dimethyl sulfoxide (DMSO) alone robustly induces TE differentia...
ORGANISM(S): Homo sapiens (Human) 
2026-03-12 | PXD069054 | Pride
Blastoids  trophectoderm differentiation  dimethyl sulfoxide  v-atpase  lysosomal acidification 
GenomicsPRC2 shields naïve human pluripotent cells from trophectoderm and mesoderm differentiation [scRNA-seq]
PRC2 shields naïve human pluripotent cells from trophectoderm and mesoderm differentiation [scRNA-seq]
PRJNA804150 | ENA
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