tumor associated macrophages

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unidentified (1)
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Organisms

Mus musculus (714)
Homo sapiens (422)
Rattus norvegicus (5)
Canis lupus familiaris (4)
Danio rerio (3)
Mus musculus musculus (2)
Drosophila melanogaster (1)
gut metagenome (1)

Repository

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Tissue

Macrophage (31)
Cell culture (15)
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Brooke-Spiegler syndrome (1)
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Embryonal carcinoma (1)
Female infertility (1)
Germ cell cancer (1)

Technology Type

Mass Spectrometry (68)
Shotgun proteomics (37)
Bottom-up proteomics (17)
Mass spectrometry (11)
Mass spectrometry assay (10)
Data-dependent acquisition (6)
Data-independent acquisition (6)
Gel-based experiment (5)
SWATH MS (3)
Affinity purification coupled with mass spectrometry proteomics (2)
DiaPASEF (2)
Illumina HiSeq 2500, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 2000 (1)
Illumina Genome Analyzer II (1)
All-ion fragmentation (1)
SRM/MRM (1)

Instrument Platform

Illumina NovaSeq 6000 (20)
NextSeq 500 (10)
Illumina HiSeq 4000 (8)
Illumina HiSeq 1500 (7)
Illumina HiSeq 2500 (6)
Illumina HiSeq 2000 (5)
NextSeq 550 (3)
10x Genomics Chromium (2)
Illumina Genome Analyzer II (2)
Illumina NovaSeq X (2)
NA (2)
N/A (2)
NextSeq 2000 (2)
DNBSEQ-G400 (2)
DNBelab C Series High-throughput Single-cell RNA Library Preparation Set V3.0 (MGI Tech) (1)
DNBelab C-TaiM droplet generator (MGI Tech) (1)
Avatarget 12-well dual-chamber organ-on-chip system; AvatarFlow Organ Chip Flow Initiation Controller System (Avatarget Co., Ltd., Suzhou, China) (1)
Digital Alliance of Canada (1)
AAV-CRISPR (1)
10X Dual Index Kit (1)
10X Chromium Next GEM Single-Cell 3' Kit v3.1 (1)
CellRanger v2.1.0 (1)
Python (1)
Nugen Ovation SPIA; Wafergen’s Apollo liquid handler; KAPA Hyper Prep Library Kit (1)
QIAGEN TissueLyser II (1)
Isoflurane euthanasia chamber (1)
FastPrep-24 5G bead beater, Qubit Fluorometer (1)
12 well TC-treated plate, LETs buffer, dry ice (1)
R software (1)
Nf-core pipeline (1)

Publication Date

2025 (270)
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2024 (196)
2023 (141)
2022 (109)
2012 (87)
2015 (84)
2014 (83)
2021 (80)
2013 (80)
2020 (79)
2010 (79)
2016 (66)
2011 (63)
2019 (45)
2008 (40)
2009 (35)
2018 (34)
2017 (30)
2007 (20)
2006 (7)
2004 (3)
2005 (2)
2027 (1)

CHEBI ID

CHEBI:16750 (7)
CHEBI:16737 (6)
CHEBI:17596 (6)
CHEBI:16610 (5)
CHEBI:16199 (5)
CHEBI:15428 (5)
CHEBI:16335 (5)
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CHEBI:16668 (5)
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CHEBI:30769 (5)
CHEBI:17345 (5)
CHEBI:28044 (5)
CHEBI:15891 (5)
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CHEBI:32816 (4)
CHEBI:17268 (4)
CHEBI:27897 (4)
CHEBI:18257 (4)
CHEBI:18132 (4)
CHEBI:18186 (4)
CHEBI:6650 (4)
CHEBI:16708 (4)
CHEBI:16704 (4)
CHEBI:15756 (4)
CHEBI:30915 (4)
CHEBI:17568 (4)

Metabolite Name

Glycine (5)
Creatinine (5)
Hypoxanthine (5)
Urea (4)
Tyrosine (4)
Serine (4)
Phenylalanine (4)
Hypotaurine (4)
Ornithine (4)
Taurine (4)
Adenosine (4)
Taurine (4)
Guanosine (4)
Thiamine monophosphate (4)
Creatine (4)
Adenosine (4)
Phe-Ser (3)
Cholesterol (3)
O-Phosphoethanolamine (3)
Trimethylamine N-oxide (3)
Fructose (3)
Myo-inositol (3)
Spermidine (3)
Putrescine (3)
Xanthine (3)
Valine (3)
Proline (3)
Methionine (3)
Lysine (3)
Leucine (3)

First Public Date

2026 (273)
2025 (268)
2024 (218)
2023 (134)
2022 (94)
2021 (79)
2020 (72)
2019 (48)
2014 (41)
2018 (31)
2017 (29)
2015 (17)
2016 (14)
2013 (2)

Modelling Approach

Ordinary differential equation model (1)

Study status

Completed (3)

Lab affiliation

Roswell Park Cancer Center Buffalo, NY, USA (2)
School of Chemistry and Biochemistry and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA (2)
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University (2)
1 Department of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, PR China. 2 Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province, Hubei, PR China. 3 Taikang Center for Life and Medical Sciences of Wuhan University (1)
1Department of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, PR China. 2Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province, Hubei, PR China. 3Taikang Center for Life and Medical Sciences of Wuhan University (1)
Associate professor at Macquarie University, Sydney, Australia Visiting professor at Institute for Glyco-core Research (iGCORE), Nagoya Univeristy, Aichi, Japan (1)
Beijing University of Chinese Medicine, School of Traditional Chinese Medicine, Attending Physician, Assistant Researcher (1)
Ben May Department of Cancer Research, University of Chicago (1)
Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver V5Z 1L3, Canada. (1)
Cellular and Molecular Immunology Research Unit (CMIRU), Faculty of Allied Health Science, Naresuan University, Phitsanulok, Thailand (1)
Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands (1)
Center for Tumor Biology and Immunology (ZTI), Philipps University, Hans-Meerwein-Strasse 3, 35043 Marburg, Germany (1)
Centre de Recherche en Cancérologie de Marseille, CRCM Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes 27 Boulevard Leï Roure CS30059 13273 Marseille Cedex 09 France (1)
DZNE Munich, Neuroproteomics, Feodor-Lynen Str. 17, 81377 Munich, Germany (1)
Department of Biological Engineering, Massachusetts Institute of Technology (1)
Department of Human Genetics and Biochemistry Sackler School of Medicine Tel Aviv University Tel-Aviv, Israel 69978 (1)
Department of Molecular & Integrative Physiology, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, USA (1)
Department of Molecular Biology, Faculty of Science, Oncode Institute, Radboud University Nijmegen, 6525 GA Nijmegen, The Netherlands Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands (1)
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Japan (1)
Department of Obstetrics and Gynecology, School of Medicine, Stanford University, CA, USA. Igenomix Foundation, Instituto de Investigación Sanitaria Hospital Clínico (INCLIVA), Valencia, Spain (1)
Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada (1)
Department of Pathology, UAMS, Little Rock, AR, USA 2 The Winthrop P. Rockefeller Cancer Institute, UAMS, Little Rock, AR, USA (1)
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA (1)
Dept. Chemical Proteomics, Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (1)
Director of The Breast Tumor Immunology Laboratory Women’s Cancer Program Dana-Farber Cancer Institute Instructor in Medicine Harvard Medical School (1)
Experimental Systems Immunology Laboratory, Max Planck Institute of Biochemistry, Martinsried, Germany Institute of Innate Immunity, Department of Systems Immunology and Proteomics, Medical Faculty, University of Bonn, Germany (1)
Experimental Systems Immunology Laboratory, Max Planck Institute of Biochemistry, Martinsried, Germany Institute of Innate Immunity, Department of Systems Immunology and Proteomics, Medical Faculty, University of Bonn, Germany (lab head) (1)
Faculty of Medicine and University Hospital of Cologne, Institute of Pathology, University of Cologne, Cologne, Germany (1)
First Affiliated Hospital, School of Medicine, Zhejiang University (1)
Head of Mass Spectrometry Laboratory, Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP, Brazil. (1)

Keyword

Ferrosoferric Oxide (1)
Nanoliposomal irinotecan (1)
Ferumoxytol (1)
Gastro-Esophageal Junction Adenocarcinoma (1)
MM-398 (1)
TNBC (1)
Durvalumab (1)

IsPrivate

False (1)

Study type

Transcription profiling by array (471)
RNA-seq of coding RNA (76)
RNA-seq of coding RNA from single cells (21)
ChIP-seq (19)
Unknown experiment type (12)
Transcription profiling by RT-PCR (9)
Comparative genomic hybridization by array (5)
RNA-seq of non coding RNA (4)
Transcription profiling by SAGE (3)
Methylation profiling by array (3)
One-color microarray (2)
Other (2)
Proteomic profiling by array (2)
RNA-seq of total RNA (2)
Interventional (2)
Animal - One-color microarray (1)
ChIP-chip by tiling array (1)
Human - High-throughput sequencing (1)
Animal - High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
Transcription profiling by tiling array (1)
MicroRNA profiling by high throughput sequencing (1)
ATAC-seq (1)
Hi-C (1)
Single nucleus RNA sequencing (1)
CUT&RUN (1)
Methylation profiling by high throughput sequencing (1)
Observational (1)

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2019 (364)
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2017 (252)
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2008 (58)
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2006 (12)
2004 (6)
2003 (6)
2005 (5)
2000 (4)
2002 (2)
2001 (2)
1997 (2)

Location

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United States (1)

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Metabolic Reprogramming in Tumor-Associated Macrophages during Murine Hepatocellular Carcinoma Progression

To investigate the impact of Wdr4 on the metabolic reprogramming of tumor-associated macrophages (TAMs) in hepatocellular carcinoma (HCC), we established an orthotopic HCC model in Wdr4-f/f and Wdr4 conditional knockout (Wdr4-cKO) mice. TAMs were subsequently isolated via flow cytometry-based cel...

2025-09-28 | MTBLS12764 | MetaboLights

Dynamic single-cell metabolomics reveals cell-cell interaction between tumor cells and macrophages

Single-cell metabolomics reveals cell heterogeneity and elucidates intracellular molecular mechanisms. However, general concentration measurement of metabolites can only provide a static delineation of metabolomics, lacking the metabolic activity information of biological pathways. Herein, we dev...

2025-04-14 | MTBLS11091 | MetaboLights

Macrophage-specific BCAT1 deficiency drives lipid-associated immunosuppressive remodeling and promotes HCC progression

The heterogeneous and immunosuppressive tumor microenvironment (TME) remains one of the major factors to the poor immunotherapeutic response in hepatocellular carcinoma (HCC). Tumor-associated macrophages (TAMs) are central orchestrators of this suppressive niche, yet the metabolic programs regul...

2025-12-28 | MTBLS13579 | MetaboLights

IFN-γ-driven iNOS induction in macrophages mediates CAR T cell resistance in B cell lymphoma

Chimeric antigen receptor (CAR) T cell therapies have revolutionized B cell malignancy treatment, but subsets of patients with large B cell lymphoma (LBCL) experience primary resistance or relapse after CAR T cell treatment. To uncover tumor microenvironment (TME)-induced resistance mechanisms, we e...

2026-05-31 | MTBLS14634 | MetaboLights

An Ets2-specific transcriptional program in tumor-associated macrophages promotes metastasis

Macrophages have been implicated in breast cancer progression and metastasis, but relatively little is known about the genes and pathways that are involved. Using a conditional allele of Ets2 in the mouse, we have identified Ets2 as a critical gene in tumor associated macrophages (TAMs) that specif...

ORGANISM(S): Mus musculus

2010-01-05 | E-GEOD-12863 | biostudies-arrayexpress

IFN-γ-driven iNOS induction in macrophages mediates CAR T cell resistance in B cell lymphoma (CAR-T Metabolites)

2026-05-31 | MTBLS14640 | MetaboLights

IFN-γ-driven iNOS induction in macrophages mediates CAR T cell resistance in B cell lymphoma (Glucose Tracer)

2026-05-31 | MTBLS14641 | MetaboLights

Deregulation of PPAR-beta/delta target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment - RNAseq

The transcriptome of serous ovarian cancer tumor associated macrophages was characterized. Additionally, their transcription response to PPARD agonists and inverse agonists in cell culture was analyzed.

ORGANISM(S): Homo sapiens

2015-05-31 | E-MTAB-3167 | biostudies-arrayexpress

High-density gene expression analysis of tumor-associated macrophages from mouse mammary tumors

Clinical and experimental evidence indicates that tumor-associated macrophages (TAMs) promote malignant progression. In breast cancer, TAMs enhance tumor angiogenesis, tumor cell invasion, matrix remodeling, and immune suppression against the tumor. In this study, we examined late-stage mammary tumo...

ORGANISM(S): Mus musculus

2010-06-21 | E-GEOD-18404 | biostudies-arrayexpress

Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment - ChIPseq

PPARD and RXR genome wide binding in tumor associated macrophages from serous ovarian carcinoma was characterized.

ORGANISM(S): Homo sapiens

2015-06-01 | E-MTAB-3166 | biostudies-arrayexpress

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