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TranscriptomicsCell state transitions regulated by Slug are critical for tissue regeneration and tumor initiation [Agilent microarray samples]
Alterations that perturb differentiation and cell state transitions can lead to defects in development, function and the genesis of cancer. Studying cellular plasticity at high resolution and in real time has proven difficult using existing methods. Here, we use a quantitative approach to gain insig...
ORGANISM(S): Homo sapiens 
2014-06-23 | E-GEOD-54713 | biostudies-arrayexpress
TranscriptomicseIF3a in Urinary Bladder Cancer M-bM-^@M-^S in vivo and in vitro insights
The eukaryotic translation initiation factor (eIF) 3a is described in various tumor entities as potential tumor marker involved in development and progression of cancer. eIF3a is the largest subunit of the eIF3 complex, a key functional entity in 80S establishment and translation initiation. We hypo...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-45636 | biostudies-arrayexpress
ProteomicsMatrix Gla Protein acts as a driver of stemness and tumor initiation in ovarian cancer
Ovarian cancer (OC) displays the highest mortality among gynecological tumors, mainly due to early peritoneal dissemination, the high frequency of tumor relapse following primary debulking and the development of chemoresistance. All these events are thought to be initiated and sustained by a subpopu...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037543 | Pride
Exploris 480  matrix gla protein  ovarian cancer  cancer stem cells  tumor initiation  hedgehog pathway 
TranscriptomicsNetwork Analysis of Skin Tumor Progression Identifies a Rewired Genetic Architecture Affecting Inflammation and Tumor Susceptibility (aCGH)
Background: Germline polymorphisms can influence gene expression networks in normal mammalian tissues and can affect disease susceptibility. We and others have shown that analysis of this genetic architecture can identify single genes and whole pathways that influence complex traits including inflam...
ORGANISM(S): Mus musculus 
2010-12-23 | E-GEOD-26273 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD90+ stromal fibromuscular cells from tumor specimens reveals down-regulation in prostate tumor-associated stromal cells involves organ-specific genes
The prostate stroma is a key mediator of epithelial differentiation and development, and potentially plays a role in the initiation and progression of prostate cancer. Isolation and characterization of viable populations of the constituent cell types of prostate tumors could provide valuable insight...
ORGANISM(S): Homo sapiens 
2009-09-18 | E-GEOD-17906 | biostudies-arrayexpress
TranscriptomicsStably-paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor Triptolide
Transcription by RNA Polymerase II (Pol II) in metazoan is regulated in several steps, including preinitiation complex (PIC) formation, initiation, Pol II escape, productive elongation, cotranscriptional RNA-processing and termination. Genome-wide studies have demonstrated that the phenomenon of ...
ORGANISM(S): Homo sapiens 
2015-01-05 | E-GEOD-63314 | biostudies-arrayexpress
GenomicsIdentification of the primary target of the chemotherapeutic agent CX-5461 as a late step in transcription initiation by RNA Polymerase I
In recent years, several small molecule cytotoxic drugs have been identified as potential inhibitors of ribosome biogenesis (Drygin et al., 2011; Peltonen et al., 2014a; Peltonen et al., 2014b). CX-5461 is one such drug that has also demonstrated anticancer potential for a wide range of malignancies...
ORGANISM(S): Mus musculus 
2021-04-07 | E-MTAB-9242 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of retrovirus PDGFB induced Glioma in control and Olig2cKO tumor
We performed gene expression pofiling of of Olig2cKO and control glioma tumor and identified significantly changed genes RNA-seq of control tumor tissues and Olig2cKO tumor tissues
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-71493 | biostudies-arrayexpress
TranscriptomicsBrg1 promotes both tumor suppressive and oncogenic activities at distinct stages of Pancreatic cancer formation
Pancreatic Ductal Adenocarcinoma (PDA) develops predominantly through pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) precursor lesions. Pancreatic acinar cells are reprogrammed to a “ductal like” state during PanIN-PDA formation. Here, we demonstrate ...
ORGANISM(S): Mus musculus 
2015-07-29 | E-GEOD-65315 | biostudies-arrayexpress
GenomicsGlycogen phase separation drives liver tumor initiation
Glycogen phase separation drives liver tumor initiation
PRJNA626580 | ENA
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