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Metabolomicsp53 regulates Chaperone-mediated autophagy

p53 protects against the initiation and progression of a plethora of cancers, but the mechanisms underlying this critical function remain incompletely understood. In addition, chaperone-mediated autophagy (CMA) is major form of autophagy unique to vertebrates, yet both its regulation and function...

2026-10-03 | MTBLS13190 | MetaboLights
MetabolomicsLoss of p53 exacerbates autoimmunity by reprogramming propionyl-CoA metabolism and epigenetics in Treg cells

Metabolic regulation is central to the tumor suppressor function of p53. Here we report that propionyl-CoA metabolic remodeling and epigenetic changes underpin p53-mediated restraint of autoimmunity through regulatory T (Treg) cells. By analyzing the human patients with autoimmune diseases, we fo...

2026-02-06 | MTBLS13473 | MetaboLights
TranscriptomicsExpression profiling of p53-regulated genes by cDNA microarray analysis
To characterize the molecular features of p53 signaling pathway, we generated the gene-expression profiles of p53-introduced U373MG cells by genome-wide cDNA microarrays Keywords: time course U373MG cells were infected with 20 MOI of Ad-p53 or Ad-LacZ. mRNA from infected cells were collected at 0...
ORGANISM(S): Homo sapiens 
2010-05-05 | E-GEOD-14953 | biostudies-arrayexpress
GenomicsCharacterization of the p53 cistrome - DNA binding cooperativity dissects p53's tumor suppressor functions
p53 wildtype or complementing DNA binding cooperativity versions (EE, RR, EE/RR) were overexpressed in SAOS cells and 18h later harvested to perform ChIP with an p53-specific antibody. The enriched DNA fragments were purified and identified by high throughput sequencing.
ORGANISM(S): Homo sapiens 
2014-02-14 | E-MTAB-1394 | biostudies-arrayexpress
TranscriptomicsDownregulation of LATS kinases alters p53 to promote cell migration
p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-?B subunit. Moreover, it par...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-74493 | biostudies-arrayexpress
TranscriptomicsCharacterization of the p53 cistrome - DNA binding cooperativity dissects p53's tumor suppressor functions - Expression profiling
P53 wildtype or complementing DNA binding cooperativity versions (p53EE, p53RR, p53EE/RR) were overexpressed in SAOS cells. After 18h cells were harvested and subjected to expression profiling.
ORGANISM(S): Homo sapiens 
2014-02-14 | E-MTAB-1403 | biostudies-arrayexpress
TranscriptomicsInfluence of human P53 on plant gene expression
Mammalian p53 is a super tumor suppressor and plays a key role in guarding genome from DNA damage. However, p53 has not been found in plants which do not bear cancer although they constantly expose to ionizing radiation of ultraviolet light. Here we introduced p53 into the model plant Arabidopsis an...
ORGANISM(S): Arabidopsis thaliana 
2016-06-26 | E-GEOD-79678 | biostudies-arrayexpress
ProteomicsDifferent Oligomeric States of the Tumor Suppressor p53 Show Identical Binding Behavior Towards the S100β Homodimer
The tumor suppressor protein p53 is a transcription factor that is referred to as the “guardian of the genome” and plays an important role in cancer development. P53 is active as a tetramer; the S100β homodimer binds to the intrinsically disordered C-terminus of p53, affecting its transcriptional ac...
ORGANISM(S): Escherichia coli 
2022-10-14 | PXD029914 | Pride
Cross-linking Intrinsically disordered proteins Tumor suppressor S100β P53 
GenomicsBRD7 is a candidate tumour suppressor gene required for p53 function
Oncogene-induced senescence (OIS) is a p53-dependent defence mechanism against uncontrolled proliferation. Consequently, many human tumours harbour p53 mutations while others show a dysfunctional p53 pathway, frequently by unknown mechanisms. We identified BRD7, a bromodomain-containing protein whos...
ORGANISM(S): Homo sapiens 
2010-03-14 | E-GEOD-20076 | biostudies-arrayexpress
TranscriptomicsPhosphorylation of p53 Serine 46 contributes to target gene selectivity of p53 (Exon)
The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of cellular response pathways. The molecular mechanisms that discriminate between the distinct p53-responses towards different stress treatments have remained largely elusive. Here, we have analyzed the p53-...
ORGANISM(S): Homo sapiens 
2011-03-23 | E-GEOD-22184 | biostudies-arrayexpress
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