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TranscriptomicsExpression profiling of p53-regulated genes by cDNA microarray analysis
To characterize the molecular features of p53 signaling pathway, we generated the gene-expression profiles of p53-introduced U373MG cells by genome-wide cDNA microarrays Keywords: time course U373MG cells were infected with 20 MOI of Ad-p53 or Ad-LacZ. mRNA from infected cells were collected at 0...
ORGANISM(S): Homo sapiens 
2010-05-05 | E-GEOD-14953 | biostudies-arrayexpress
Metabolomicsp53 regulates Chaperone-mediated autophagy

p53 protects against the initiation and progression of a plethora of cancers, but the mechanisms underlying this critical function remain incompletely understood. In addition, chaperone-mediated autophagy (CMA) is major form of autophagy unique to vertebrates, yet both its regulation and function...

2026-10-03 | MTBLS13190 | MetaboLights
ProteomicsRevisiting p53:Sirt1 interaction in the light of controlling p53 acetylation levels
The NAD⁺-dependent deacetylase sirtuin 1 (Sirt1) is known to regulate the tumor suppressor p53 via deacetylation, but the structural basis of the protein-protein interaction between full-length Sirt1 and p53 has so far remained elusive. We apply an integrated approach, combining structural mass spe...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD072665 | Pride
Sirtuin 1 Cross-linking Mass spectrometry P53 
TranscriptomicsA large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 transcriptional response
Recently, more than a thousand large intergenic non-coding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biological processes. Here, we report the identification of lincRNAs that are regulated by p53. One of ...
ORGANISM(S): Mus musculus 
2010-08-09 | E-GEOD-21761 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human p53+ and p53- fibroblasts treated with arsenite reveals exit from arsenite-induced mitotic arrest is p53 dependent
Microarray data from G2-synchronized p53(+) and p53(-) fibroblasts before and after 3 h release from cell cycle blockade in the presence of 5 uM sodium arsenite. Experiment Overall Design: Cells expressing p53 from a tet-off regulated construct were synchronized in G2 with a two-step procedure using...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-7101 | biostudies-arrayexpress
GenomicsCharacterization of the p53 cistrome - DNA binding cooperativity dissects p53's tumor suppressor functions
p53 wildtype or complementing DNA binding cooperativity versions (EE, RR, EE/RR) were overexpressed in SAOS cells and 18h later harvested to perform ChIP with an p53-specific antibody. The enriched DNA fragments were purified and identified by high throughput sequencing.
ORGANISM(S): Homo sapiens 
2014-02-14 | E-MTAB-1394 | biostudies-arrayexpress
GenomicsPhosphorylation of p53 Serine 46 contributes to target gene selectivity of p53 (ChIP-seq)
The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of cellular response pathways. The molecular mechanisms that discriminate between the distinct p53-responses towards different stress treatments have remained largely elusive. Here, we have analyzed the p53-...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-21939 | biostudies-arrayexpress
TranscriptomicsPhosphorylation of p53 Serine 46 contributes to target gene selectivity of p53 (Exon)
The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of cellular response pathways. The molecular mechanisms that discriminate between the distinct p53-responses towards different stress treatments have remained largely elusive. Here, we have analyzed the p53-...
ORGANISM(S): Homo sapiens 
2011-03-23 | E-GEOD-22184 | biostudies-arrayexpress
GenomicsGlobal genomic profiling of p53-regulated genes
p53 is a critical tumor suppressor and works as a stress-induced transcription factor to induce target genes mediating apoptosis, cell cycle arrest and senescence or other responses. To gain new insights into p53 biology, we used high-throughput sequencing to analyze global p53 transcriptional netwo...
ORGANISM(S): Mus musculus 
2013-04-21 | E-GEOD-46240 | biostudies-arrayexpress
TranscriptomicsInfluence of human P53 on plant gene expression
Mammalian p53 is a super tumor suppressor and plays a key role in guarding genome from DNA damage. However, p53 has not been found in plants which do not bear cancer although they constantly expose to ionizing radiation of ultraviolet light. Here we introduced p53 into the model plant Arabidopsis an...
ORGANISM(S): Arabidopsis thaliana 
2016-06-26 | E-GEOD-79678 | biostudies-arrayexpress
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