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GenomicsTumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells
Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells
PRJNA1425022 | ENA
ProteomicsB-Cell-based Therapy Controls Glioblastoma Growth by Producing Antibodies that Inhibit Tumor Invasion and Migration
Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor with limited therapeutic options and poor prognosis. Despite current treatments, the invasive nature of GBM often leads to recurrence. A promising alternative strategy is to harness the immune system's potential against t...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-09-10 | PXD046712 | Pride
Glioblastoma multiforme (gbm)  b-cell-based vaccine (bvax)  tumor-reactive antibodies  immunoproteomics 
TranscriptomicsTumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells
The presence of B cells in tumors is correlated with a positive prognosis in several types of cancers, including high-grade serous ovarian cancer (HGSOC). These cells give rise to plasma cells (PCs) that originate from germinal centers (GCs) and secrete tumor-reactive antibodies. GCs also give rise ...
ORGANISM(S): Homo sapiens 
2026-05-26 | GSE319733 | GEO
UnknownB7-H1 antibodies lose antitumor activity due to activation of p38 MAPK that leads to apoptosis of tumor-reactive CD8+ T cells.
Not available
S-EPMC5099859 | biostudies-literature
TranscriptomicsSingle-cell ATAC sequencing of SIINFEKL-reactive T cells in GL261 murine brain tumors in MHC class II deficient tumor-mircoenvironments
Single cell ATAC sequencing of SIINFEKL-reactive immune cell from intracranial murine GL261-SIINFEKL tumors 20 days after inoculation. SIINFEKL-reactive T cells were sorted based on dextramer staining. We show that loss of major histocompatibility complex (MHC) class II (MHCII)-restricted antigen pr...
ORGANISM(S): Mus musculus 
2023-01-11 | E-MTAB-12512 | biostudies-arrayexpress
ProteomicsIgM Abs to Apoptosis-associated Determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells
Natural antibodies, which arise without known immune exposure, have been described that specifically recognize cells dying from apoptosis but their role in innate immunity remains poorly understood. Herein, we show that the immune response to neo-antigenic determinants on apoptotic thymocytes is dom...
ORGANISM(S): Mus musculus 
2009-02-23 | E-GEOD-14958 | biostudies-arrayexpress
UnknownNeutrophil-derived reactive oxygen species promote tumor colonization.
Not available
S-EPMC8277858 | biostudies-literature
UnknownIdentification of tumor-reactive B cells and systemic IgG in breast cancer based on clonal frequency in the sentinel lymph node.
Not available
S-EPMC6368991 | biostudies-literature
UnknownA cross-reactive pH-dependent EGFR antibody with improved tumor selectivity and penetration obtained by structure-guided engineering.
Not available
S-EPMC9703009 | biostudies-literature
UnknownCharacterization of the tumor marker muc16 (ca125) expressed by murine ovarian tumor cell lines and identification of a panel of cross-reactive monoclonal antibodies.
Not available
S-EPMC2708168 | biostudies-literature
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