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MetabolomicsRegional HNSCC metabolomics reveals widespread changes to one-carbon metabolism and S-adenosylmethionine metabolism across tumour core, tumour edge and adjacent non-tumour tissues

Cancer, including head and neck squamous cell carcinoma (HNSCC), induces changes to metabolism that drive the disease. Regional metabolomics can help to understand metabolic variation across the tumour including changes near the tumour core, where hypoxia is likely more pronounced. We apply ultra...

2026-06-03 | MTBLS1905 | MetaboLights
MetabolomicsBrown-fat-mediated tumour suppression by cold-altered global metabolism

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold an...

2022-08-12 | MTBLS4856 | MetaboLights
MetabolomicsEffects of hypoxic preconditioning on neuroblastoma tumour oxygenation and metabolic signature in a chick embryo model
Hypoxia episodes and areas in tumours have been associated with metastatic dissemination and poor prognosis. Given the link between tumour tissue oxygen levels and cellular metabolic activity, we hypothesised that the metabolic profile between metastatic and non-metastatic tumours would reveal poten...
2018-08-13 | MTBLS541 | MetaboLights
MetabolomicsMitochondrial respiration controls neoangiogenesis during wound healing and tumour growth

The vasculature represents a highly plastic compartment, capable of switching from a quiescent to an active proliferative state during angiogenesis. Metabolic reprogramming in endothelial cells (ECs) thereby is crucial to cover the increasing cellular energy demand under growth conditions. Here w...

2020-06-29 | MTBLS1764 | MetaboLights
MetabolomicsCancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-canc...
2018-07-10 | MTBLS626 | MetaboLights
MetabolomicsFatty acid synthesis in colorectal cancer: characterization of lipid metabolism in serum, tumour, and normal host tissues
The objective of the experiment was to compare serum fatty acid metabolite abundance between individuals with varying clinical stages of colorectal cancer (stage I-IV) and age-and-gender matched disease-free controls. Fatty acid metabolite abundance was compared between locoregional (stage I-III) an...
2016-12-15 | MTBLS27 | MetaboLights
TranscriptomicsComparative genomic hybridization of 17 favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome
We have carried out microarray-based comparative genomic hybridisation (arrayCGH) on 17 Favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome. Tumour DNA was co-hybridised with normal female genomic D...
ORGANISM(S): Homo sapiens 
2006-05-11 | E-TABM-13 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of 100 favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome
We have carried out microarray-based comparative genomic hybridisation (arrayCGH) on 100 favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome. Tumour DNA was co-hybridised with normal female genomic ...
ORGANISM(S): Homo sapiens 
2006-05-11 | E-TABM-10 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of colorectal cancer
We profile single cells from patients with colorectum cancer using Chromium 3’ and 5’ single-cell RNA-sequencing. Patients EXT001, EXT009, and EXT012 from the KUL dataset were first analyzed by Lee et al., 2020, and the raw data are available in ArrayExpress under the accession codes E-MTAB-8410 and...
ORGANISM(S): Homo sapiens 
2022-09-16 | E-MTAB-9934 | biostudies-arrayexpress
TranscriptomicsDownregulation of three tumour suppressor genes SLC26A3, DCN and TPM1 in colorectal cancer
Despite identification of major genes and pathways involved in development of colorectal cancer (CRC) it became obvious that several steps in these pathways might be bypassed by other yet unknown genetic events that lead towards CRC. To improve our understanding of the genetic mechanisms of CRC deve...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-14010 | biostudies-arrayexpress
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