Sort   by:  
 Page size 
TranscriptomicsPromoter directionality is controlled by U1 snRNP and polyadenylation signals
Transcription of the mammalian genome is pervasive, but productive transcription outside of protein-coding genes is limited by unknown mechanisms. In particular, although RNA polymerase II (RNAPII) initiates divergently from most active gene promoters, productive elongation occurs primarily in the s...
ORGANISM(S): Mus musculus 
2013-06-28 | E-GEOD-46433 | biostudies-arrayexpress
TranscriptomicsiCLIP and NGS to map protein-RNA interactions for U1-snRNP proteins in Trypanosoma brucei
Individual-nucleotide resolution UV-crosslinking and immunoprecipitation (iCLIP) combined with high-throughput sequencing was performed to generate genome-wide binding maps of two U1-snRNP proteins: U1C and U1-70K in Trypanosoma brucei. 3 (2) biological replicates of U1C (U1-70K) -specific co-immuno...
ORGANISM(S): Trypanosoma brucei 
2014-05-16 | E-GEOD-43848 | biostudies-arrayexpress
ProteomicsSequence specific recognition of U1 snRNP stem-loop 4 by the ubiquitin-like domain of U2 snRNP protein SF3A1 and its RGG motif
Cross-linking of isotope-labelled RNA coupled with mass spectrometry (CLIR-MS) was used to study the interaction between the ubiquitin-like domain (UBL) of the protein SF3A1, a component of the U2 snRNP, with stem-loop 4 RNA (SL4) from the U1 snRNP. The complex was cross-linked and analysed both in ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD027189 | Pride
Uv cross-linking  sf3a1  u1  u2  snrnp  splicing  spliceosome  structural proteomics  protein-rna  rna-protein  protein-rna complex  rna-protein complex  clir-ms 
ProteomicsU1 snRNP and RNA polymerase II interaction is predominantly mediated by Prp40 rather than U1-70K in yeast
Transcription and splicing are coupled both temporally and physically. A previous cryo-EM structure of the human U1 snRNP and RNA polymerase pol II complex has shown that U1 snRNP uses predominantly the RRM domain of U1-70K to directly interact with the RPB2 subunit of pol II. However, residues on U...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-05-20 | PXD078573 | Pride
Yeast Spliceosome Splicing Pol ii Snrnp Prp40 
GenomicsNeuronal stimulation changes U1 snRNP binding and intronic polyadenylation
Neuronal stimulation changes U1 snRNP binding and intronic polyadenylation
PRJNA770346 | ENA
GenomicsThe Arabidopsis U1 snRNP regulates mRNA 3’-end processing
The Arabidopsis U1 snRNP regulates mRNA 3’-end processing
PRJEB65251 | ENA
TranscriptomicsALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP
The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron disease ALS, is demonstrated to directly bind to the U1-snRNP and SMN complexes. ALS-causative mutations in FUS/TLS are shown to abnormally enhance their interaction with SMN and reduce interaction with U1-snRN...
ORGANISM(S): Homo sapiens 
2015-02-10 | E-GEOD-64078 | biostudies-arrayexpress
GenomicsU1 snRNP regulates alternative promoter activity by inhibiting premature polyadenylation
U1 snRNP regulates alternative promoter activity by inhibiting premature polyadenylation
PRJNA1200036 | ENA
TranscriptomicsNuclear Matrix Factor hnRNP U/SAF-A Exerts a Global Control of Alternative Splicing by Regulating U2 snRNP Maturation
The nuclear matrix associated hnRNP U/SAF-A protein has been implicated in diverse pathways from transcriptional regulation to telomere length control to X inactivation, but the precise mechanism underlying each of these processes has remained elusive. Here, we report hnRNP U as a regulator of SM...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-34491 | biostudies-arrayexpress
GenomicsU1 snRNP regulates chromatin retention of noncoding RNAs
U1 snRNP regulates chromatin retention of noncoding RNAs
PRJNA554651 | ENA
Sort   by:  
 Page size