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ProteomicsGPLD1 Attenuates Heart Failure via Dual Membrane Localization to inhibit uPAR
GPLD1 levels were elevated in HF patients and murine models. Cardiac-specific GPLD1 depletion exacerbated cardiac dysfunction and hypertrophy, while its overexpression ameliorated these effects, dependent on enzymatic activity. uPAR was identified as a potential binding target for GPLD1, and viral-m...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD064470 | Pride
Heart failure  upar  pi(4 5)p2  calcium homeostasis. Gpld1 
GenomicsCAR T cells targeting uPAR are effective senolytics
CAR T cells targeting uPAR are effective senolytics
PRJNA607785 | ENA
GenomicsAnti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness
Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness
PRJNA976249 | ENA
GenomicsAnti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness
Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness
PRJNA1285389 | ENA
GenomicsUrokinase plasminogen activator receptor (uPAR) attenuates allergen-induced eosinophil migration and airway hyperresponsiveness through distinct mechanisms
Urokinase plasminogen activator receptor (uPAR) attenuates allergen-induced eosinophil migration and airway hyperresponsiveness through distinct mechanisms
PRJNA1263207 | ENA
UnknownAntagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration.
Not available
S-EPMC2930687 | biostudies-literature
GenomicsUrokinase plasminogen activator receptor (uPAR) attenuates allergen-induced eosinophil migration and airway hyperresponsiveness through distinct mechanisms [CD45+]
Urokinase plasminogen activator receptor (uPAR) attenuates allergen-induced eosinophil migration and airway hyperresponsiveness through distinct mechanisms [CD45+]
PRJNA1263210 | ENA
TranscriptomicsCAR T cells targeting uPAR are effective senolytics
Cellular senescence is a stress-response program characterized by stable cell cycle arrest and a secretory program that modulates the tissue microenvironment. Physiologically, senescence serves as a potent tumor suppressive mechanism that prevents the expansion of premalignant cells and plays a bene...
ORGANISM(S): Mus musculus 
2020-04-18 | GSE145642 | GEO
TranscriptomicsAnti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness
This SuperSeries is composed of the SubSeries listed below. Intestinal stem cells (ISCs) drive the rapid regeneration of the gut epithelium. However, during aging their regenerative capacity is reduced, possibly through senescence and chronic inflammation, albeit little is known about how aging-asso...
ORGANISM(S): Mus musculus 
2025-10-13 | GSE301534 | GEO
TranscriptomicsAnti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness
Intestinal stem cells (ISCs) drive the rapid regeneration of the gut epithelium. However, during aging their regenerative capacity is reduced, possibly through senescence and chronic inflammation, albeit little is known about how aging-associated dysfunction arises in the intestine. We previously id...
ORGANISM(S): Mus musculus 
2025-10-13 | GSE233431 | GEO
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