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MetabolomicsExercise Activates Interferon Immune Response of the Liver via Gpld1 to Enhance Antiviral Innate Immunity

Healthy behavioral patterns could modulate organ functions to enhance the body’s immunity. However, whether exercise regulates antiviral innate immunity remains elusive. Here, we found that exercise promotes type-I IFN (IFN-I) production in the liver and enhances IFN-I immune activity of the body...

2024-04-24 | MTBLS7972 | MetaboLights
ProteomicsGPLD1 Attenuates Heart Failure via Dual Membrane Localization to inhibit uPAR
GPLD1 levels were elevated in HF patients and murine models. Cardiac-specific GPLD1 depletion exacerbated cardiac dysfunction and hypertrophy, while its overexpression ameliorated these effects, dependent on enzymatic activity. uPAR was identified as a potential binding target for GPLD1, and viral-m...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD064470 | Pride
Heart failure  upar  pi(4 5)p2  calcium homeostasis. Gpld1 
UnknownCap-independent translation of GPLD1 enhances markers of brain health in long-lived mutant and drug-treated mice.
Not available
S-EPMC9470888 | biostudies-literature
UnknownExercise activates interferon response of the liver via Gpld1 to enhance antiviral innate immunity.
Not available
S-EPMC11804790 | biostudies-literature
UnknownProstasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor.
Not available
S-EPMC2271112 | biostudies-literature
TranscriptomicsLIVER EXERCISE FACTOR REVERSES AGING AND ALZHEIMER’S-RELATED MEMORY LOSS BY TARGETING BRAIN VASCULATURE
Blood factors transfer the benefits of exercise to the aged brain. However, mechanisms to restore cognition and the translational application to neurodegenerative disorders are unknown. Here we show that liver-derived exercise factor glycosylphosphatidylinositol (GPI)-specific phospholipase D1(Gpld1...
ORGANISM(S): Mus musculus 
2026-03-11 | GSE269061 | GEO
TranscriptomicsLIVER EXERCISE FACTOR REVERSES AGING- AND ALZHEIMER’S-RELATED MEMORY LOSS BY TARGETING BRAIN VASCULATURE
Blood factors transfer the benefits of exercise to the aged brain, independent of physical activity. Here we show that liver-derived exercise factor glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (GPLD1), a GPI-degrading enzyme, reverses aging- and Alzheimer’s-related memory loss by ta...
ORGANISM(S): Mus musculus 
2026-02-09 | GSE304483 | GEO
GenomicsLIVER EXERCISE FACTOR REVERSES AGING AND ALZHEIMER’S-RELATED MEMORY LOSS BY TARGETING BRAIN VASCULATURE
LIVER EXERCISE FACTOR REVERSES AGING AND ALZHEIMER’S-RELATED MEMORY LOSS BY TARGETING BRAIN VASCULATURE
PRJNA1120039 | ENA
UnknownBlood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.
Not available
S-EPMC7879650 | biostudies-literature
GenomicsLIVER EXERCISE FACTOR REVERSES AGING- AND ALZHEIMER’S-RELATED MEMORY LOSS BY TARGETING BRAIN VASCULATURE
LIVER EXERCISE FACTOR REVERSES AGING- AND ALZHEIMER’S-RELATED MEMORY LOSS BY TARGETING BRAIN VASCULATURE
PRJNA1301371 | ENA
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