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ProteomicsPharmacological Targeting of Casein Kinase 1δ Suppresses Oncogenic NRAS-Driven Melanoma
Activating mutations in NRAS account for 20-30% of melanoma, yet effective anti-NRAS therapies are still lacking. In this study, we unveil the casein kinase 1δ (CK1δ) as an uncharacterized regulator of oncogenic NRAS mutations, specifically Q61R and Q61K, which are the most prevalent NRAS mutations ...
ORGANISM(S): Homo sapiens (Human) 
2024-09-20 | PXD046277 | Pride
Oncogenic nras melanomagenesis  melanoma progression ck1δ  usp46. 
TranscriptomicsHPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes
Cervical cancer is one of the most common cancers in women. More than 95% of the cervical cancers are caused by the human papilloma viruses. Earlier we had identified a protein target, USP46 that can be inhibited to block the cancer growth. We found that the viral E6 and human USP46 complex increase...
ORGANISM(S): Homo sapiens 
2021-12-20 | GSE191010 | GEO
GenomicsHPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes
HPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes
PRJNA789318 | ENA
ProteomicsA novel miniTurbo knock-in mouse reveals a protein interaction network of USP46 in the brain
To characterize the protein interaction network of USP46, BioID analysis was conducted on a knock-in cell line that expresses USP46 and biotin ligase fusion protein stably.
ORGANISM(S): Mus Musculus (mouse) 
2026-03-12 | PXD064961 | JPOST Repository
UnknownThe deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking.
Not available
S-EPMC4668950 | biostudies-literature
UnknownThe USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.
Not available
S-EPMC10556042 | biostudies-literature
UnknownThe Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers.
Not available
S-EPMC6294304 | biostudies-literature
UnknownHPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes.
Not available
S-EPMC8750077 | biostudies-literature
UnknownA novel miniTurbo knock-in mouse reveals a protein interaction network of USP46 in the brain.
Not available
S-EPMC12826572 | biostudies-literature
UnknownDownregulated expression levels of USP46 promote the resistance of ovarian cancer to cisplatin and are regulated by PUM2.
Not available
S-EPMC7893694 | biostudies-literature
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