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ProteomicsMOLT-4 radiosensitization by VE-821
DNA damage induction by either radio- or chemo-therapy has been the most widely used approach in cancer therapy, exploiting the genomic instability of cancer cells. A promising strategy takes advantage of tumour specific abnormalities in DNA damage response. Inhibition of the ATR/Chk1 pathway has be...
ORGANISM(S): Homo sapiens (Human) 
2018-07-16 | PXD008925 | Pride
Ionizing radiation  small-molecule kinase inhibitors  ve-821  atr kinase  dna damage response  radio-sensitization  quantitative shotgun phosphoproteomics  titanium dioxide chromatography  silac  leukemia  molt-4 cells 
TranscriptomicsBET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc- induced lymphoma cells
The aim of the project was to determine the expression profiles of murine Myc-driven lymphpma cells (Lambda-820) treated with vehicle (DMSO, 1:1000), a BET inhibitor (RVX2135), an ATR inhibitor (VE-821) or a combination of RVX2135 and VE-821. All experimnets were performed in presence of 10uM Q-VD-O...
ORGANISM(S): Mus musculus 
2015-12-18 | E-GEOD-74873 | biostudies-arrayexpress
UnknownThe ATR inhibitor VE-821 increases the sensitivity of gastric cancer cells to cisplatin.
Not available
S-EPMC10400920 | biostudies-literature
UnknownThe novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy.
Not available
S-EPMC3461814 | biostudies-literature
UnknownThe ATR Inhibitor VE-821 Enhances the Radiosensitivity and Suppresses DNA Repair Mechanisms of Human Chondrosarcoma Cells.
Not available
S-EPMC9917087 | biostudies-literature
UnknownZEB1 inhibition sensitizes cells to the ATR inhibitor VE-821 by abrogating epithelial-mesenchymal transition and enhancing DNA damage.
Not available
S-EPMC5969561 | biostudies-literature
UnknownRadiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): phosphoproteomic analysis.
Not available
S-EPMC4139827 | biostudies-literature
UnknownRadio-sensitizing effects of VE-821 and beyond: Distinct phosphoproteomic and metabolomic changes after ATR inhibition in irradiated MOLT-4 cells.
Not available
S-EPMC6042708 | biostudies-literature
UnknownSynergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821.
Not available
S-EPMC4899226 | biostudies-literature
UnknownATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses.
Not available
S-EPMC4252598 | biostudies-literature
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