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MetabolomicsAnalysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors

Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in children and adults in endemic areas. Gene regulation of ETEC during growth in vitro and in vivo needs to be further evaluated, and here we describe the full transcriptome and metabolome of ETEC dur...

2022-07-15 | MTBLS3540 | MetaboLights
ProteomicsMapping of Functional SARS-CoV-2 Receptors in Human Lungs Establishes Differences in Variant Binding and SLC1A5 as a Viral Entry Modulator of hACE2
The COVID-19 pandemic is an infectious disease caused by SARS-CoV-2. The first step of SARS-CoV-2 infection is the recognition of angiotensin-converting enzyme 2 (hACE2) receptors by the receptor-binding domain (RBD) of the viral spike (S) glycoprotein. Although the molecular and structural bases of...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD038005 | Pride
Spike  super resolution microscopy  ace2 co-factors  rbd  viral binding  viral entry 
TranscriptomicsThe role of integrins in human cytomegalovirus (HCMV)-infected monocytes.
We have established that human cytomegalovirus (HCMV) infection modulates the biology of target primary blood monocytes, allowing HCMV to use monocytes as 'vehicles' for its systemic spread. HCMV infection of monocytes results in rapid induction of PI(3)K and NF-kB activity. Integrins, which are u...
ORGANISM(S): Homo sapiens 
2010-10-31 | E-GEOD-24238 | biostudies-arrayexpress
GenomicsViral entry defines the hepatitis E virus species barrier in murine hepatocytes
Viral entry defines the hepatitis E virus species barrier in murine hepatocytes
PRJNA1421980 | ENA
ProteomicsCD46 regulates hepatitis B virus entry by modulating cell-surface NTCP levels through cis-interaction
Hepatitis B virus (HBV) infection remains a major global health challenge. While sodium taurocholate co-transporting polypeptide (NTCP) is the primary receptor for HBV entry, the molecular mechanisms regulating NTCP-mediated viral entry remain incompletely understood. Here, we identified CD46 as a c...
ORGANISM(S): Homo Sapiens (human) 
2026-01-13 | PXD065037 | JPOST Repository
GenomicsCRISPR screen using pseudotyped viruses identifies specific entry factors for viral infection
CRISPR screen using pseudotyped viruses identifies specific entry factors for viral infection
PRJNA1289857 | ENA
ProteomicsViral Entry Shapes HCMV Latency Establishment
Human Cytomegalovirus (HCMV) infection can result in either productive or latent infection, the latter being the basis for the virus life-long persistence. Intriguingly, monocytes, which support latent infection, become permissive to productive infection upon differentiation to macrophages. However,...
ORGANISM(S): Homo sapiens (Human) 
2025-12-25 | PXD071694 | Pride
ProteomicsGPI-Anchored Ligand-BioID2-Tagging System Identifies proteins Mediating Zika Virus Entry
Identification of host factors facilitating pathogen entry is critical for preventing infectious diseases. Here, we report a tagging system consisting of a viral receptor-binding protein (RBP) linked to BioID2, which is expressed on the cell surface via a GPI anchor. Using VSV or Zika virus (ZIKV) R...
ORGANISM(S): Homo Sapiens 
2022-10-12 | PXD037307 |
TranscriptomicsPolysome purified mRNA in control and RACK1 silenced in human hepatocarcinoma cells
Fighting viral infections is hampered by the scarcity of viral targets and their variability resulting in development of resistance. Viruses depend on cellular molecules for their life cycle, which are attractive alternative targets, provided that they are dispensable for normal cell functions. Usin...
ORGANISM(S): Homo sapiens 
2015-05-14 | E-GEOD-60374 | biostudies-arrayexpress
GenomicsChronobiology of Neurotropic Viruses: Rhythmic Viral Entry and Arrhythmic Host Clocks
Chronobiology of Neurotropic Viruses: Rhythmic Viral Entry and Arrhythmic Host Clocks
PRJNA1366578 | ENA
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