Sort   by:  
 Page size 
MetabolomicsA benchmark spike-in data set for biomarker identification in metabolomics
The development and the validation of innovative approaches for biomarker selection are of paramount importance in many -omics technologies. Unfortunately, the actual testing of new methods on real data is difficult, because in real data sets, one can never be sure about the “true” biomarkers. In th...
2013-10-24 | MTBLS59 | MetaboLights
MetabolomicsUrine Latin Square Spike-In for testing the NMR quantification tool, MetaboQuant
To test the quantification performance of MetaboQuant and other NMR quantification tools, a set of eight metabolites were added to replicates of a urine sample in varying concentrations. The metabolites were alanine, creatinine, histidine, betaine, acetate, phosphocreatine, β-hydroxybutyrate (BHBA) ...
2013-01-10 | MTBLS25 | MetaboLights
MetabolomicsPomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs
Plant extracts are rich in bioactive compounds, such as polyphenols, sesquiterpenes, and triterpenes, which potentially have antiviral activities. As a consequence of the coronavirus disease 2019 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, thousands of...
2021-10-06 | MTBLS2309 | MetaboLights
TranscriptomicsComparison of systematic sequencing errors using spike-in standards
While the importance of random sequencing errors decreases at higher DNA or RNA sequencing depths, systematic sequencing errors (SSEs) dominate at high sequencing depths and can be difficult to distinguish from biological variants. These SSEs can cause base quality scores to underestimate the proba...
ORGANISM(S): Homo sapiens 
2012-03-03 | E-GEOD-36217 | biostudies-arrayexpress
ProteomicsHCOV-NL63 spike protein glycopeptides
HCoV-NL63 is a coronavirus that can cause severe lower respiratory tract infections requiring hospitalization. Of great interest is understanding the HCoV-NL63 coronavirus spike glycoprotein trimer, which is the conformational machine responsible for entry into host cells and the sole target of neut...
ORGANISM(S): Human Coronavirus Nl63 (ncbitaxon:277944) 
2020-03-13 | MSV000085098 | MassIVE
ProteomicsStructural dynamics in the evolution of SARS-CoV-2 spike glycoprotein: HDX-MS analysis of the spike of the original Wuhan isolate, G614 spike mutant, and the isolated ancestral RBD - in apo state and in complex with the ACE2 receptor
The spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates binding to the ACE2 receptor and subsequent membrane fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 receptor, and an open state that does so but displa...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD039760 | Pride
Sars-cov-2 Spike glycoprotein Hdx-ms 
ProteomicsStructural dynamics in the evolution of SARS-CoV-2 spike glycoprotein: HDX-MS analysis of the spike of alpha, beta, delta and omicron variants - in apo state and in complex with the ACE2 receptor
The spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates binding to the ACE2 receptor and subsequent membrane fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 receptor, and an open state that does so but displa...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD039762 | Pride
Sars-cov-2 Spike glycoprotein Hdx-ms 
ProteomicsStructural- and Site-specific N-glycosylation Characterization of COVID-19 Virus Spike with StrucGP
Spike (S) protein plays a key role in COVID-19 (SARS-CoV-2) infection and host-cell entry. Previous studies have systematically analyzed site-specific glycans compositions of S protein. Here, we further provide structure-clear N-glycosylation of S protein at site-specific level by using our recently...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034086 | Pride
Covid-19 Lc-msms Strucgp Spike Glycopeptides 
ProteomicsCross-linking mass spectrometry uncovers interactions between high-density lipoproteins and the SARS-CoV-2 spike glycoprotein
Multiple studies to date have shown that high-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and that the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to play a key role during the lifecycle of he...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD042625 | Pride
Hdl Spike Xlms. cov 
ProteomicsData-independent acquisition mass spectrometry for site-specific glycoproteomics characterization of SARS-CoV-2 spike protein
The spike protein of SARS-CoV-2, the virus responsible for the global pandemic of COVID-19, is an abundant, heavily glycosylated surface protein that plays a key role in receptor binding and host cell fusion, and is the focus of all current vaccine development efforts. Variants of concern are now ci...
ORGANISM(S): Homo sapiens (Human) 
2022-09-12 | PXD027279 | Pride
Glycosylation Dia Glycoproteomics Sars-cov-2 Mass spectrometry Spike protein 
Sort   by:  
 Page size