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MetabolomicsDeep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation

Bordetella pertussis is the bacterial causative agent of whooping cough, a serious respiratory illness. An extensive knowledge on its virulence regulation and metabolism is a key factor to ensure pertussis vaccine manufacturing process robustness. The aim of this study was to refine our ...

2023-02-21 | MTBLS5762 | MetaboLights
ProteomicsExploring potential virulence regulators in Paracoccidioides brasiliensis isolates of varying virulence through quantitative proteomics
Paracoccidioides brasiliensis is the agent of paracoccidioidomycosis, an important systemic mycosis in Latin America. Few virulence factors have been identified for this pathogen. In this study, we quantitatively evaluated the protein composition of P. brasiliensis in the yeast phase using minimal a...
ORGANISM(S): Paracoccidioides brasiliensis (strain Pb18) 
2014-08-28 | PXD000804 | Pride
Paracoccidioides brasiliensis  pathogenic fungus  proteomic analysis  virulence regulators 
TranscriptomicsTranscriptional profiling of 14 regulators required for Salmonella virulene
To cause a systemic infection, Salmonella must respond to many environmental cues during mouse infection and express specific subsets of genes in a temporal and spatial manner, but the regulatory pathways are poorly established. To unravel how micro-environmental signals are processed and integrated...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S 
2012-05-30 | E-GEOD-38378 | biostudies-arrayexpress
MetabolomicsPhosphoproteomic and Metabolomic Profiling Uncovers the Roles of CcPmk1 in the Pathogenicity of Cytospora chrysosperma

Pmk1, a highly conserved pathogenicity-related mitogen-activated protein kinase (MAPK) in pathogenic fungi, is phosphorylated and activated by MAP2K and acts as a global regulator of fungal infection and invasive growth by modulating downstream targets. However, the hierarchical CcPmk1 regulatory...

2022-07-11 | MTBLS4463 | MetaboLights
TranscriptomicsControl of Virulence Gene Expression in Citrobacter rodentium by Trascription Factor RegA
Identification of the targets of RegA with and without bicarbonate stimulation by comparing RegA knockout to multicopy RegA transgenics. RegA is an AraC like transcription factor identified in a mutational screen for virulence genes in Citrobacter rodentium, an attaching and effacing pathogen that ...
ORGANISM(S): Citrobacter rodentium 
2010-05-19 | E-GEOD-12876 | biostudies-arrayexpress
GenomicsChIP-seq analyses of 10 quorum sensing regulators in Pseudomonas aeruginosa
The Pseudomonas aeruginosa quorum-sensing (QS) systems contribute to bacterial homeostasis and pathogenicity. Although many regulators have been characterized to control the production of virulence factors and QS signaling molecules, its detailed regulatory mechanisms still remain elusive. Here, we ...
ORGANISM(S): Pseudomonas aeruginosa 
2015-08-04 | E-GEOD-65356 | biostudies-arrayexpress
GenomicsInterplay between two peroxide stress regulators in the oxidative stress response and virulence of pathogenic Leptospira
Interplay between two peroxide stress regulators in the oxidative stress response and virulence of pathogenic Leptospira
PRJNA663862 | ENA
GenomicsCell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators
Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators
PRJNA230623 | ENA
ProteomicsThe purine biosynthesis regulator PurR moonlights as a virulence regulator in Staphylococcus aureus
To adapt to different environments, S. aureus relies on a complex and finely tuned regulatory network. While some of these networks have been well elucidated, the functions of more than 50% of the transcriptional regulators in S. aureus remain unexplored. Here, we assess the contribution of the LacI...
ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) 
2019-06-06 | MSV000083904 | MassIVE
GenomicsRegulons and protein–protein interactions of PRD-containing Bacillus anthracis virulence regulators reveal overlapping but distinct functions
Regulons and protein–protein interactions of PRD-containing Bacillus anthracis virulence regulators reveal overlapping but distinct functions
PRJNA639101 | ENA
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