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MetabolomicsCell-to-cell heterogeneity drives host-virus coexistence in a bloom-forming alga

Algal blooms drive global biogeochemical cycles of key nutrients in the oceans and serve as hotspots for biological interactions. The massive spring blooms of the cosmopolitan coccolithophore Emiliania huxleyi (E. huxleyi) are often infected by the lytic Emiliania huxleyi

2024-01-04 | MTBLS1956 | MetaboLights
MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
TranscriptomicsDynamics and Characterization of Small RNAs of Virus and Host Origin from Wheat Streak Mosaic Virus- and/or Triticum Mosaic Virus-infected Susceptible and Temperature-Sensitive Resistant Wheat Cultivars
Wheat streak mosaic virus (WSMV) and Triticum mosaic virus (TriMV) are type members of Tritimovirus and Poacevirus genera, respectively, in the family Potyviridae, and are transmitted by wheat curl mites. Co-infection of these two viruses causes synergistic interaction with increased virus accumula...
ORGANISM(S): Triticum aestivum 
2014-12-01 | E-GEOD-54026 | biostudies-arrayexpress
MetabolomicsIn plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids (Imaging MS assays)

Tapping into the metabolic cross-talk between a host and its virus can reveal unique strategies employed during infection. Viral infection is a dynamic process that generates an evolving metabolic landscape. Gaining a continuous view into the infection process is highly challenging and is limited...

2018-11-29 | MTBLS769 | MetaboLights
TranscriptomicsTMV-derived Small RNAs Reveals Role for Arabidopsis thaliana RNA-dependent RNA Polymerases in Viral siRNA Biogenesis
Using a crucifer-infecting strain of Tobacco Mosaic Virus (TMV-Cg) and Arabidopsis thaliana as a model system, we analyzed the viral small RNA profile in wild-type plants as well as rdr mutants by applying small RNA deep sequencing technology. Over 100,000 TMV-Cg-specific small RNA reads, mostly of...
ORGANISM(S): Youcai mosaic virus 
2009-03-24 | E-GEOD-12918 | biostudies-arrayexpress
MetabolomicsIn plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids (GC- and LC-MS assays)

Tapping into the metabolic cross-talk between a host and its virus can reveal unique strategies employed during infection. Viral infection is a dynamic process that generates an evolving metabolic landscape. Gaining a continuous view into the infection process is highly challenging and is limited...

2018-11-29 | MTBLS767 | MetaboLights
ModelsInfluenza A Virus Replication Cycle
The replication and life cycle of the influenza virus is governed by an intricate network of intracellular regulatory events during infection, including interactions with an even more complex system of biochemical interactions of the host cell. Computational modeling and systems biology have been su...
3481 | Cell Collective
TranscriptomicsThe Relationship between Virus Replication and Host Gene Expression in Lymphatic Tissue during HIV-1 Infection
During HIV-1 infection, there is a massive perturbation of host gene expression, but as yet, genome-wide studies have not identified host genes affecting HIV-1 replication in lymphatic tissue, the primary site of virus-host interactions. In this study, we isolated RNA from the inguinal lymph nodes ...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-21589 | biostudies-arrayexpress
TranscriptomicsHost-influenza A virus(infA) interactions
This SuperSeries is composed of the following subset Series: GSE36461: MiRNA profiling during infection with H1N1 influenza A virus (A/Mexico/InDRE4487/H1N1/2009) GSE36462: MiRNA profiling during infection with H7N7 influenza A virus (A/Ck/Germany/R28/H7N7/2003) GSE36553: mRNA profiling during infec...
ORGANISM(S): Homo sapiens 
2012-04-09 | E-GEOD-36555 | biostudies-arrayexpress
ProteomicsStructural Host Virus Interactome Profiling of Intact Infected Cells
Virus-host protein-protein interactions (PPIs) are fundamental to viral infections, yet high-resolution identification within the native context of intact infected cells has remained an unsolved challenge. Here, we developed structural host-virus interactome profiling (SHVIP) that combines in situ c...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2025-06-13 | PXD047422 | Pride
Virus Ppi Hsv-1 Xl-ms Shvip Herpes 
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