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TranscriptomicsVitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis
Hippocampal apoptosis is a characteristic feature of penumococcal meningitis associated with learning and memory deficitis as a sequel of the disease. We investigated the effect of vitamin B6 using an established infant rat model of experimental pneumococcal meningitis by histomorphology, transcript...
ORGANISM(S): Rattus norvegicus 
2012-02-20 | E-MEXP-3555 | biostudies-arrayexpress
MetabolomicsNicotinamide Riboside is Uniquely Bioavailable in People and Mice
Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we conducted experiments to determine the time and dose-dependent effects of NR on blood, liver and heart NAD+ metabolism in people and mice. We report that human blood cell NAD+ can rise as much as 2.7-fold with a single d...
2016-09-09 | MTBLS368 | MetaboLights
GenomicsThe white adipose tissue transcriptional response to withdrawal of vitamin B3
The white adipose tissue transcriptional response to withdrawal of vitamin B3
PRJNA478790 | ENA
GenomicsNutritional Genomics Uncovers Vitamin B3 Therapy as Curative for NAXD Disease
Nutritional Genomics Uncovers Vitamin B3 Therapy as Curative for NAXD Disease
PRJNA1301136 | ENA
TranscriptomicsThe white adipose tissue transcriptional response to withdrawal of vitamin B3
Distinct markers for early, mild vitamin B3 deficiency are lacking. To identify these, we examined the molecular responses of white adipose tissue to vitamin B3 withdrawal. We performed a dietary intervention in male C57Bl/6JRcc mice. A diet with a low but adequate level of tryptophan without nicoti...
ORGANISM(S): Mus musculus 
2019-05-06 | GSE116483 | GEO
TranscriptomicsNutritional Genomics Uncovers Vitamin B3 Therapy as Curative for NAXD Disease
Vitamins are essential metabolites that must be obtained from external sources. All 13 vitamins were identified in the early 1900s, a rich era of biochemistry. More recently, they are consumed indiscriminately. We introduce a new nutritional genomics framework that begins with a treatment and identi...
ORGANISM(S): Mus musculus 
2026-02-06 | GSE304377 | GEO
TranscriptomicsThe effect of nicotinamide on dysregulated genes associated with frataxin deficiency in FRDA.
To investigate the efficacy of nicotinamide treatment using our ex-vivo primary lymphocyte model, we performed high-throughput RNA sequencing on libraries generated from untreated and nicotinamide treated samples. PBMC isolated from FRDA affected individuals were cultured to prepare the primary lymp...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-42960 | biostudies-arrayexpress
TranscriptomicsTranscription of human thrombopoietin-induced megakaryocyte differentiation with and without nicotinamide vs. Universal reference sample
Culture of hematopoietic stem and progenitor cells in the presence of thrombopoietin induces megakaryocytic differentiation. Addition of nicotinamide to thrombopoietin-stimulated cultures results in significant increases in megkaryocytic differentiation including greater polyploidization and enhanc...
ORGANISM(S): Homo sapiens 
2009-04-08 | E-GEOD-4974 | biostudies-arrayexpress
UnknownTranscriptional Response of White Adipose Tissue to Withdrawal of Vitamin B3.
Not available
S-EPMC6618275 | biostudies-literature
UnknownNicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme.
Not available
S-EPMC5446048 | biostudies-literature
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